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Home / Assay Kits / ELISA Kits

ELISA Kit for Human HLA class II histocompatibility antigen gamma chain

SKU : BHE13805390

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E13627h
Alternative Names	HLA-DR antigens-associated invariant chain ; Ia antigen-associated invariant chain ; Ii ; p33 ; CD74 ; DHLAG
Categories	Elisa
Function	Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.
Specificity	Natural and recombinant Human HLA class II histocompatibility antigen gamma chain
Subcellular Location	Cell membrane Single-pass type II membrane protein Endoplasmic reticulum membrane Golgi apparatus trans-Golgi network Endosome Lysosome Transits through a number of intracellular compartments in the endocytic pathway. It can either undergo proteolysis or reach the cell membrane.
Detection Range	0.625-40ng/mL
Entryname	HG2A_HUMAN
Method Type	Sandwich
Platform	PF09307
Protein Name	HLA class II histocompatibility antigen gamma chain
Sensitivity	0.156ng/ml
Sequence	50: MHRRRSRSCR ; EDQKPVMDDQ ; RDLISNNEQL ; PMLGRRPGAP ; ESKCSRGALY ; 100: TGFSILVTLL ; LAGQATTAYF ; LYQQQGRLDK ; LTVTSQNLQL ; ENLRMKLPKP ; 150: PKPVSKMRMA ; TPLLMQALPM ; GALPQGPMQN ; ATKYGNMTED ; HVMHLLQNAD ; 200: PLKVYPPLKG ; SFPENLRHLK ; NTMETIDWKV ; FESWMHHWLL ; FEMSRHSLEQ ; 250: KPTDAPPKVL ; TKCQEEVSHI ; PAVHPGSFRP ; KCDENGNYLP ; LQCYGSIGYC ; 296: WCVFPNGTEV ; PNTRSRGHHN ; CSESLELEDP ; SSGLGVTKQD ; LGPVPM
Sequence Length	296
String	P04233
Sub Unit	Homotrimer. In the endoplasmic reticulum (ER) it forms an heterononameric MHC II-Ii complex: 3 MHC class II molecules (heterodimers of an alpha and a beta subunit) bind to the CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system, the CD74 component undergoes sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide) attached to the MHC class II molecule (alpha-beta-CLIP complex). This processed complex interacts with HLA_DM and HLA_DO heterodimers in order to release CLIP and facilitate the binding of antigenic peptides to the MHC class II molecules.

Uniprot	P04233
Gene Name	CD74
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:972
Unigene	Hs.436568

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SKU	Supplier No.	Size	Your price	Quantity
BHE13805390	E13627h	96T	$736		Add to Cart

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