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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Histone deacetylase 8

SKU : BHE13805620

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1111h
Alternative Names	HDACL1 ; CDA07
Categories	Elisa
Function	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. May play a role in smooth muscle cell contractility.
Specificity	Natural and recombinant Human Histone deacetylase 8
Subcellular Location	Nucleus Cytoplasm Excluded from the nucleoli. Found in the cytoplasm of cells showing smooth muscle differentiation.
Detection Range	0.625-40ng/mL
Entryname	HDAC8_HUMAN
Method Type	Sandwich
Platform	PF00850
Protein Name	Histone deacetylase 8
Sensitivity	0.32ng/mL
Sequence	50: MEEPEEPADS ; GQSLVPVYIY ; SPEYVSMCDS ; LAKIPKRASM ; VHSLIEAYAL ; 100: HKQMRIVKPK ; VASMEEMATF ; HTDAYLQHLQ ; KVSQEGDDDH ; PDSIEYGLGY ; 150: DCPATEGIFD ; YAAAIGGATI ; TAAQCLIDGM ; CKVAINWSGG ; WHHAKKDEAS ; 200: GFCYLNDAVL ; GILRLRRKFE ; RILYVDLDLH ; HGDGVEDAFS ; FTSKVMTVSL ; 250: HKFSPGFFPG ; TGDVSDVGLG ; KGRYYSVNVP ; IQDGIQDEKY ; YQICESVLKE ; 300: VYQAFNPKAV ; VLQLGADTIA ; GDPMCSFNMT ; PVGIGKCLKY ; ILQWQLATLI ; 350: LGGGGYNLAN ; TARCWTYLTG ; VILGKTLSSE ; IPDHEFFTAY ; GPDYVLEITP ; 377: SCRPDRNEPH ; RIQQILNYIK ; GNLKHVV
Sequence Length	377
String	Q9BY41
Sub Unit	Interacts with PEPB2-MYH11, a fusion protein consisting of the 165 N-terminal residues of CBF-beta (PEPB2) with the tail region of MYH11 produced by the inversion Inv(16)(p13q22), a translocation associated with acute myeloid leukemia of M4EO subtype. The PEPB2-MYH1 fusion protein also interacts with RUNX1, a well known transcriptional regulator, suggesting that the interaction with HDAC8 may participate in the conversion of RUNX1 into a constitutive transcriptional repressor. Interacts with CBFA2T3. Interacts with phosphorylated SMG5/EST1B; this interaction protects SMG5 from ubiquitin-mediated degradation. Associates with alpha-SMA (smooth muscle alpha-actin).

Uniprot	Q9BY41
Gene Name	HDAC8
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:55869
Unigene	Hs.310536

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SKU	Supplier No.	Size	Your price	Quantity
BHE13805620	E1111h	96T	$736		Add to Cart

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