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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Heat shock cognate 71 kDa protein

SKU : BHE13806199

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1094h
Antigen	HSPA8
Alternative Names	Heat shock 70 kDa protein 8 ; Lipopolysaccharide-associated protein 1 ; LAP-1 ; HSC70 ; HSP73 ; HSPA10
Categories	Elisa
Function	Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Isoform 2 may function as an endogenous inhibitory regulator of HSC70 by competing the co-chaperones.
Specificity	Natural and recombinant Human Heat shock cognate 71 kDa protein
Subcellular Location	Cytoplasm Melanosome Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Translocates rapidly from the cytoplasm to the nuclei, and especially to the nucleoli, upon heat shock. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Detection Range	0.312-20ng/mL
Entryname	HSP7C_HUMAN
Method Type	Sandwich
Platform	PF00012
Protein Name	Heat shock cognate 71 kDa protein
Sensitivity	0.15ng/mL
Sequence	50: MSKGPAVGID ; LGTTYSCVGV ; FQHGKVEIIA ; NDQGNRTTPS ; YVAFTDTERL ; 100: IGDAAKNQVA ; MNPTNTVFDA ; KRLIGRRFDD ; AVVQSDMKHW ; PFMVVNDAGR ; 150: PKVQVEYKGE ; TKSFYPEEVS ; SMVLTKMKEI ; AEAYLGKTVT ; NAVVTVPAYF ; 200: NDSQRQATKD ; AGTIAGLNVL ; RIINEPTAAA ; IAYGLDKKVG ; AERNVLIFDL ; 250: GGGTFDVSIL ; TIEDGIFEVK ; STAGDTHLGG ; EDFDNRMVNH ; FIAEFKRKHK ; 300: KDISENKRAV ; RRLRTACERA ; KRTLSSSTQA ; SIEIDSLYEG ; IDFYTSITRA ; 350: RFEELNADLF ; RGTLDPVEKA ; LRDAKLDKSQ ; IHDIVLVGGS ; TRIPKIQKLL ; 400: QDFFNGKELN ; KSINPDEAVA ; YGAAVQAAIL ; SGDKSENVQD ; LLLLDVTPLS ; 450: LGIETAGGVM ; TVLIKRNTTI ; PTKQTQTFTT ; YSDNQPGVLI ; QVYEGERAMT ; 500: KDNNLLGKFE ; LTGIPPAPRG ; VPQIEVTFDI ; DANGILNVSA ; VDKSTGKENK ; 550: ITITNDKGRL ; SKEDIERMVQ ; EAEKYKAEDE ; KQRDKVSSKN ; SLESYAFNMK ; 600: ATVEDEKLQG ; KINDEDKQKI ; LDKCNEIINW ; LDKNQTAEKE ; EFEHQQKELE ; 646: KVCNPIITKL ; YQSAGGMPGG ; MPGGFPGGGA ; PPSGGASSGP ; TIEEVD
Sequence Length	646
String	P11142
Sub Unit	Interacts with HSPH1/HSP105. Interacts with IRAK1BP1 (By similarity). Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts with PACRG and TSC2. Interacts with BAG1. Interacts with SV40 VP1. Interacts with DNAJC7 (By similarity). Interacts with HERC5. Interacts with CITED1 (via N-terminus); the interaction suppresses the association of CITED1 to p300/CBP and Smad-mediated transcription transactivation.

Uniprot	P11142
Gene Name	HSPA8
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:3312
Unigene	Hs.180414

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SKU	Supplier No.	Size	Your price	Quantity
BHE13806199	E1094h	96T	$736		Add to Cart

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