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ELISA Kit for Human Granulocyte colony-stimulating factor receptor

SKU : BHE13803192

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2217h
Alternative Names	CD114 ; GCSFR
Categories	Elisa
Function	Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface.
Specificity	Natural and recombinant Human Granulocyte colony-stimulating factor receptor
Subcellular Location	Cell membrane Single-pass type I membrane protein
Detection Range	31.2-2000pg/mL
Entryname	CSF3R_HUMAN
Method Type	Sandwich
Platform	PF00041
Protein Name	Granulocyte colony-stimulating factor receptor
Sensitivity	15.78pg/mL
Sequence	50: MARLGNCSLT ; WAALIILLLP ; GSLEECGHIS ; VSAPIVHLGD ; PITASCIIKQ ; 100: NCSHLDPEPQ ; ILWRLGAELQ ; PGGRQQRLSD ; GTQESIITLP ; HLNHTQAFLS ; 150: CCLNWGNSLQ ; ILDQVELRAG ; YPPAIPHNLS ; CLMNLTTSSL ; ICQWEPGPET ; 200: HLPTSFTLKS ; FKSRGNCQTQ ; GDSILDCVPK ; DGQSHCCIPR ; KHLLLYQNMG ; 250: IWVQAENALG ; TSMSPQLCLD ; PMDVVKLEPP ; MLRTMDPSPE ; AAPPQAGCLQ ; 300: LCWEPWQPGL ; HINQKCELRH ; KPQRGEASWA ; LVGPLPLEAL ; QYELCGLLPA ; 350: TAYTLQIRCI ; RWPLPGHWSD ; WSPSLELRTT ; ERAPTVRLDT ; WWRQRQLDPR ; 400: TVQLFWKPVP ; LEEDSGRIQG ; YVVSWRPSGQ ; AGAILPLCNT ; TELSCTFHLP ; 450: SEAQEVALVA ; YNSAGTSRPT ; PVVFSESRGP ; ALTRLHAMAR ; DPHSLWVGWE ; 500: PPNPWPQGYV ; IEWGLGPPSA ; SNSNKTWRME ; QNGRATGFLL ; KENIRPFQLY ; 550: EIIVTPLYQD ; TMGPSQHVYA ; YSQEMAPSHA ; PELHLKHIGK ; TWAQLEWVPE ; 600: PPELGKSPLT ; HYTIFWTNAQ ; NQSFSAILNA ; SSRGFVLHGL ; EPASLYHIHL ; 650: MAASQAGATN ; STVLTLMTLT ; PEGSELHIIL ; GLFGLLLLLT ; CLCGTAWLCC ; 700: SPNRKNPLWP ; SVPDPAHSSL ; GSWVPTIMEE ; DAFQLPGLGT ; PPITKLTVLE ; 750: EDEKKPVPWE ; SHNSSETCGL ; PTLVQTYVLQ ; GDPRAVSTQP ; QSQSGTSDQV ; 800: LYGQLLGSPT ; SPGPGHYLRC ; DSTQPLLAGL ; TPSPKSYENL ; WFQASPLGTL ; 836: VTPAPSQEDD ; CVFGPLLNFP ; LLQGIRVHGM ; EALGSF
Sequence Length	836
String	Q99062
Sub Unit	Homodimer. The dimeric receptor binds two CSF3 molecules.

Uniprot	Q99062
Gene Name	CSF3R
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:1441
Unigene	Hs.524517

Reference	1. "Expression cloning of a human granulocyte colony-stimulating factor receptor: a structural mosaic of hematopoietin receptor, immunoglobulin, and fibronectin domains." Larsen A., Davis T., Curtis B.M., Gimpel S., Sims J.E., Cosman D., Park L., Sorensen E., March C.J., Smith C.A. J. Exp. Med.172:1559-1570(1990) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 4) tissue: Placenta. 2. "Three different mRNAs encoding human granulocyte colony-stimulating factor receptor." Fukunaga R., Seto Y., Mizushima S., Nagata S. Proc. Natl. Acad. Sci. U.S.A.87:8702-8706(1990) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3) tissue: Placenta. 3. "Chromosomal gene organization of the human granulocyte colony-stimulating factor receptor." Seto Y., Fukunaga R., Nagata S. J. Immunol.148:259-266(1992) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] 4. SeattleSNPs variation discovery resource Submitted (2002-09) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS THR-231; ASN-320; ARG-346; LYS-405; GLN-440; HIS-510; HIS-562 AND CYS-583 5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1) tissue: Blood. 6. "Extracellular domain of granulocyte-colony stimulating factor receptor. Interaction with its ligand and identification of a domain in close proximity of ligand-binding region." Haniu M., Horan T., Arakawa T., Le J., Katta V., Rohde M.F. Arch. Biochem. Biophys.324:344-356(1995) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 234-269 7. "Functional domains of the granulocyte colony-stimulating factor receptor." Fukunaga R., Ishizaka-Ikeda E., Pan C.-X., Seto Y., Nagata S. EMBO J.10:2855-2865(1991) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DOMAINS 8. "Identification of a nonsense mutation in the granulocyte-colony-stimulating factor receptor in severe congenital neutropenia." Dong F., Hoefsloot L.H., Schelen A.M., Broeders C.A., Meijer Y., Veerman A.J., Touw I.P., Lowenberg B. Proc. Natl. Acad. Sci. U.S.A.91:4480-4484(1994) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;POSSIBLE ASSOCIATION WITH SCN 9. "Granulocyte colony-stimulating factor and its receptor in normal myeloid cell development, leukemia and related blood cell disorders." Touw I.P., van de Geijn G.J. Front. Biosci.12:800-815(2007) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW 10. "Clinical implications of ELA2-, HAX1-, and G-CSF-receptor (CSF3R) mutations in severe congenital neutropenia." Zeidler C., Germeshausen M., Klein C., Welte K. Br. J. Haematol.144:459-467(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POSSIBLE ASSOCIATION WITH SCN 11. "Solution structure of an extracellular domain containing the WSxWS motif of the granulocyte colony-stimulating factor receptor and its interaction with ligand." Yamasaki K., Naito S., Anaguchi H., Ohkubo T., Ota Y. Nat. Struct. Biol.4:498-504(1997) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 227-334 12. "Identification of a ligand-binding site on the granulocyte colony-stimulating factor receptor by molecular modeling and mutagenesis." Layton J.E., Iaria J., Smith D.K., Treutlein H.R. J. Biol. Chem.272:29735-29741(1997) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: 3D-STRUCTURE MODELING OF 125-331 13. "Homodimeric cross-over structure of the human granulocyte colony-stimulating factor (GCSF) receptor signaling complex." Tamada T., Honjo E., Maeda Y., Okamoto T., Ishibashi M., Tokunaga M., Kuroki R. Proc. Natl. Acad. Sci. U.S.A.103:3135-3140(2006) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 25-333 IN COMPLEX WITH CSF3;GLYCOSYLATION AT ASN-134;DISULFIDE BONDS;SUBUNIT 14. "Novel point mutation in the extracellular domain of the granulocyte colony-stimulating factor (G-CSF) receptor in a case of severe congenital neutropenia hyporesponsive to G-CSF treatment." Ward A.C., van Aesch Y.M., Gits J., Schelen A.M., de Koning J.P., van Leeuwen D., Freedman M.H., Touw I.P. J. Exp. Med.190:497-507(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HIS-229;CHARACTERIZATION OF VARIANT HIS-229;POSSIBLE ASSOCIATION WITH SCN 15. "An activating mutation in the CSF3R gene induces a hereditary chronic neutrophilia." Plo I., Zhang Y., Le Couedic J.P., Nakatake M., Boulet J.M., Itaya M., Smith S.O., Debili N., Constantinescu S.N., Vainchenker W., Louache F., de Botton S. J. Exp. Med.206:1701-1707(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT NEUTROPHILIA ASN-640

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