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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Glucocorticoid receptor

SKU : BHE13804583

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1608h
Alternative Names	Nuclear receptor subfamily 3 group C member 1 ; GRL
Categories	Elisa
Function	Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE) and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation. Involved in nuclear translocation.
Specificity	Natural and recombinant Human Glucocorticoid receptor
Subcellular Location	Isoform Beta Nucleus Localized largely in the nucleus.
Detection Range	31.2-2000pg/mL
Entryname	GCR_HUMAN
Method Type	Sandwich
Platform	PF02155
Protein Name	Glucocorticoid receptor
Sensitivity	23pg/mL
Sequence	50: MDSKESLTPG ; REENPSSVLA ; QERGDVMDFY ; KTLRGGATVK ; VSASSPSLAV ; 100: ASQSDSKQRR ; LLVDFPKGSV ; SNAQQPDLSK ; AVSLSMGLYM ; GETETKVMGN ; 150: DLGFPQQGQI ; SLSSGETDLK ; LLEESIANLN ; RSTSVPENPK ; SSASTAVSAA ; 200: PTEKEFPKTH ; SDVSSEQQHL ; KGQTGTNGGN ; VKLYTTDQST ; FDILQDLEFS ; 250: SGSPGKETNE ; SPWRSDLLID ; ENCLLSPLAG ; EDDSFLLEGN ; SNEDCKPLIL ; 300: PDTKPKIKDN ; GDLVLSSPSN ; VTLPQVKTEK ; EDFIELCTPG ; VIKQEKLGTV ; 350: YCQASFPGAN ; IIGNKMSAIS ; VHGVSTSGGQ ; MYHYDMNTAS ; LSQQQDQKPI ; 400: FNVIPPIPVG ; SENWNRCQGS ; GDDNLTSLGT ; LNFPGRTVFS ; NGYSSPSMRP ; 450: DVSSPPSSSS ; TATTGPPPKL ; CLVCSDEASG ; CHYGVLTCGS ; CKVFFKRAVE ; 500: GQHNYLCAGR ; NDCIIDKIRR ; KNCPACRYRK ; CLQAGMNLEA ; RKTKKKIKGI ; 550: QQATTGVSQE ; TSENPGNKTI ; VPATLPQLTP ; TLVSLLEVIE ; PEVLYAGYDS ; 600: SVPDSTWRIM ; TTLNMLGGRQ ; VIAAVKWAKA ; IPGFRNLHLD ; DQMTLLQYSW ; 650: MFLMAFALGW ; RSYRQSSANL ; LCFAPDLIIN ; EQRMTLPCMY ; DQCKHMLYVS ; 700: SELHRLQVSY ; EEYLCMKTLL ; LLSSVPKDGL ; KSQELFDEIR ; MTYIKELGKA ; 750: IVKREGNSSQ ; NWQRFYQLTK ; LLDSMHEVVE ; NLLNYCFQTF ; LDKTMSIEFP ; 777: EMLAEIITNQ ; IPKYSNGNIK ; KLLFHQK
Sequence Length	777
String	P04150
Sub Unit	Heteromultimeric cytoplasmic complex with HSP90, HSP70, and FKBP5 or another immunophilin, or the immunophilin homolog PPP5C. Directly interacts with UNC45A. Upon ligand binding FKBP5 dissociates from the complex and FKBP4 takes its place, thereby linking the complex to dynein and mediating transport to the nucleus, where the complex dissociates (By similarity). Binds to DNA as a homodimer, and as a heterodimer with NR3C2 or the retinoid X receptor. Binds STAT5A and STAT5B homodimers and heterodimers. Interacts with NRIP1, POU2F1, POU2F2 and TRIM28. Interacts with NCOA1, NCOA3, SMARCA4, SMARCC1, SMARCD1, and SMARCE1 (By similarity). Interacts with several coactivator complexes, including the SMARCA4 complex, CREBBP/EP300, TADA2L and p160 coactivators such as NCOA2 and NCOA6. Interaction with BAG1 inhibits transactivation. Interacts with HEXIM1, PELP1 and TGFB1I1.

Uniprot	P04150
Gene Name	NR3C1
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:2908
Unigene	Hs.122926

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SKU	Supplier No.	Size	Your price	Quantity
BHE13804583	E1608h	96T	$736		Add to Cart

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