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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Gamma-secretase-activating protein

SKU : BHE13805025

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2079h
Alternative Names	Protein pigeon homolog ; PION
Categories	Elisa
Function	Regulator of gamma-secretase activity, which specifically activates the production of beta-amyloid protein (beta-amyloid protein 40 and beta-amyloid protein 42), without affecting the cleavage of other gamma-secretase targets such has Notch. The gamma-secretase complex is an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Specifically promotes the gamma-cleavage of APP CTF-alpha (also named APP-CTF) by the gamma-secretase complex to generate beta-amyloid, while it reduces the epsilon-cleavage of APP CTF-alpha, leading to a low production of AICD.
Specificity	Natural and recombinant Human Gamma-secretase-activating protein
Subcellular Location	Golgi apparatus trans-Golgi network
Detection Range	1.56-100ng/mL
Entryname	GSAP_HUMAN
Method Type	Sandwich
Platform	PF14959
Protein Name	Gamma-secretase-activating protein
Sensitivity	0.78ng/mL
Sequence	50: MALRLVADFD ; LGKDVLPWLR ; AQRAVSEASG ; AGSGGADVLE ; NDYESLHVLN ; 100: VERNGNIIYT ; YKDDKGNVVF ; GLYDCQTRQN ; ELLYTFEKDL ; QVFSCSVNSE ; 150: RTLLAASLVQ ; STKEGKRNEL ; QPGSKCLTLL ; VEIHPVNNVK ; VLKAVDSYIW ; 200: VQFLYPHIES ; HPLPENHLLL ; ISEEKYIEQF ; RIHVAQEDGN ; RVVIKNSGHL ; 250: PRDRIAEDFV ; WAQWDMSEQR ; LYYIDLKKSR ; SILKCIQFYA ; DESYNLMFEV ; 300: PLDISLSNSG ; FKLVNFGCDY ; HQYRDKFSKH ; LTLCVFTNHT ; GSLCVCYSPK ; 350: CASWGQITYS ; VFYIHKGHSK ; TFTTSLENVG ; SHMTKGITFL ; NLDYYVAVYL ; 400: PGHFFHLLNV ; QHPDLICHNL ; FLTGNNEMID ; MLPHCPLQSL ; SGSLVLDCCS ; 450: GKLYRALLSQ ; SSLLQLLQNT ; CLDCEKMAAL ; HCALYCGQGA ; QFLEAQIIQW ; 500: ISENVSACHS ; FDLIQEFIIA ; SSYWSVYSET ; SNMDKLLPHS ; SVLTWNTEIP ; 550: GITLVTEDIA ; LPLMKVLSFK ; GYWEKLNSNL ; EYVKYAKPHF ; HYNNSVVRRE ; 600: WHNLISEEKT ; GKRRSAAYVR ; NILDNAVKVI ; SNLEARNLGP ; RLTPLLQEED ; 650: SHQRLLMGLM ; VSELKDHFLR ; HLQGVEKKKI ; EQMVLDYISK ; LLDLICHIVE ; 700: TNWRKHNLHS ; WVLHFNSRGS ; AAEFAVFHIM ; TRILEATNSL ; FLPLPPGFHT ; 750: LHTILGVQCL ; PLHNLLHCID ; SGVLLLTETA ; VIRLMKDLDN ; TEKNEKLKFS ; 800: IIVRLPPLIG ; QKICRLWDHP ; MSSNIISRNH ; VTRLLQNYKK ; QPRNSMINKS ; 850: SFSVEFLPLN ; YFIEILTDIE ; SSNQALYPFE ; GHDNVDAEFV ; EEAALKHTAM ; 854: LLGL
Sequence Length	854
String	A4D1B5
Sub Unit	Interacts with APP; specifically interacts with the CTF-alpha product of APP. Interacts with the gamma-secretase complex.

Uniprot	A4D1B5
Gene Name	GSAP
Kegg	hsa:54103
Unigene	Hs.186649

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SKU	Supplier No.	Size	Your price	Quantity
BHE13805025	E2079h	96T	$736		Add to Cart

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