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ELISA Kit for Human Galectin-9

SKU : BHE13806385

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0445h
Alternative Names	Ecalectin ; Tumor antigen HOM-HD-21
Categories	Elisa
Function	Binds galactosides. Has high affinity for the Forssman pentasaccharide. May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. Inhibits cell proliferation. It is a ligand for HAVCR2/TIM3. Induces T-helper type 1 lymphocyte (Th1) death. Isoform Short acts as an eosinophil chemoattractant.
Specificity	Natural and recombinant Human Galectin-9
Subcellular Location	Cytoplasm Secreted May also be secreted by a non-classical secretory pathway.
Detection Range	78-5000pg/mL
Entryname	LEG9_HUMAN
Method Type	Sandwich
Platform	PF00337
Protein Name	Galectin-9
Sensitivity	31pg/mL
Sequence	50: MAFSGSQAPY ; LSPAVPFSGT ; IQGGLQDGLQ ; ITVNGTVLSS ; SGTRFAVNFQ ; 100: TGFSGNDIAF ; HFNPRFEDGG ; YVVCNTRQNG ; SWGPEERKTH ; MPFQKGMPFD ; 150: LCFLVQSSDF ; KVMVNGILFV ; QYFHRVPFHR ; VDTISVNGSV ; QLSYISFQNP ; 200: RTVPVQPAFS ; TVPFSQPVCF ; PPRPRGRRQK ; PPGVWPANPA ; PITQTVIHTV ; 250: QSAPGQMFST ; PAIPPMMYPH ; PAYPMPFITT ; ILGGLYPSKS ; ILLSGTVLPS ; 300: AQRFHINLCS ; GNHIAFHLNP ; RFDENAVVRN ; TQIDNSWGSE ; ERSLPRKMPF ; 350: VRGQSFSVWI ; LCEAHCLKVA ; VDGQHLFEYY ; HRLRNLPTIN ; RLEVGGDIQL ; 355: THVQT
Sequence Length	355
String	O00182
Sub Unit	Monomer.

Uniprot	O00182
Gene Name	LGALS9
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:3965
Unigene	Hs.81337

Reference	1. "Molecular definition of a novel human galectin which is immunogenic in patients with Hodgkin's disease." Tuereci O., Schmitt H., Fadle N., Pfreundschuh M., Sahin U. J. Biol. Chem.272:6416-6422(1997) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT) tissue: Spleen. 2. "Human galectin-9 isoform full-length cDNA from gastric adenocarcinoma." Kato S. Submitted (1997-09) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG) tissue: Gastric carcinoma. 3. "Human ecalectin, a variant of human galectin-9, is a novel eosinophil chemoattractant produced by T lymphocytes." Matsumoto R., Matsumoto H., Seki M., Hata M., Asano Y., Kanegasaki S., Stevens R.L., Hirashima M. J. Biol. Chem.273:16976-16984(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT);VARIANT SER-5 4. "Cloning and expression of human urate transporter mRNA." Nakajima H., Shichiri M., Hamaguchi T. Submitted (1997-10) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT) tissue: Kidney. tissue: Stomach. 5. "Homo sapiens galectin-9 (LGALS9) / ecalectin gene, exon 2 through 11." Akiyama S. Submitted (2000-03) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] 6. "Genomic organization of the human galectin-9 gene." Graessler J., Spitzenberger F., Schroeder H.E. Submitted (2000-03) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] 7. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (2005-04) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SHORT);VARIANT SER-5 tissue: Gastric mucosa. 8. Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.more... Submitted (2005-07) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] 9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SHORT) tissue: Colon. 10. "The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity." Zhu C., Anderson A.C., Schubart A., Xiong H., Imitola J., Khoury S.J., Zheng X.X., Strom T.B., Kuchroo V.K. Nat. Immunol.6:1245-1252(2005) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS LIGAND FOR HAVCR2/TIM3 11. "Structural analysis of the human galectin-9 N-terminal carbohydrate recognition domain reveals unexpected properties that differ from the mouse orthologue." Nagae M., Nishi N., Nakamura-Tsuruta S., Hirabayashi J., Wakatsuki S., Kato R. J. Mol. Biol.375:119-135(2008) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 1-148 IN COMPLEXES WITH LACTOSE AND COMPLEX BETA-GALACTOSIDE;SUBUNIT;CARBOHYDRATE SPECIFICITY;FUNCTION 12. "Crystal structure of N-terminal domain of human galectin-9 containing L-acetyllactosamine." RIKEN structural genomics initiative (RSGI) Submitted (2008-04) to the PDB data bank [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.17 ANGSTROMS) OF 1-150 IN COMPLEX WITH L-ACETYLLACTOSAMINE 13. "Structural analysis of the recognition mechanism of poly-N-acetyllactosamine by the human galectin-9 N-terminal carbohydrate recognition domain." Nagae M., Nishi N., Murata T., Usui T., Nakamura T., Wakatsuki S., Kato R. Glycobiology19:112-117(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.3 ANGSTROMS) OF 1-148 IN COMPLEXES WITH N-ACETYLLACTOSAMINE OLIGOMERS;FUNCTION 14. "X-ray structures of human galectin-9 C-terminal domain in complexes with a biantennary oligosaccharide and sialyllactose." Yoshida H., Teraoka M., Nishi N., Nakakita S., Nakamura T., Hirashima M., Kamitori S. J. Biol. Chem.285:36969-36976(2010) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 186-323 IN COMPLEXES WITH OLIGOSACCHARIDES

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