JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
[email protected]

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / Assay Kits / ELISA Kits

ELISA Kit for Human Furin

SKU : BHE13804290

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Request More Infos

EIAAB SCIENCE INC, WUHAN

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Mfr.No.	E9700h
Alternative Names	Dibasic-processing enzyme ; Paired basic amino acid residue-cleaving enzyme ; PACE ; FUR ; PACE ; PCSK3
Categories	Elisa
Function	Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif.
Specificity	Natural and recombinant Human Furin
Subcellular Location	Golgi apparatus trans-Golgi network membrane Single-pass type I membrane protein Cell membrane Single-pass type I membrane protein Shuttles between the trans-Golgi network and the cell surface. Propeptide cleavage is a prerequisite for exit of furin molecules out of the endoplasmic reticulum (ER). A second cleavage within the propeptide occurs in the trans Golgi network (TGN), followed by the release of the propeptide and the activation of furin.
Detection Range	0.156-10ng/mL
Entryname	FURIN_HUMAN
Method Type	Sandwich
Platform	PF01483
Protein Name	Furin
Sensitivity	0.049ng/mL
Sequence	50: MELRPWLLWV ; VAATGTLVLL ; AADAQGQKVF ; TNTWAVRIPG ; GPAVANSVAR ; 100: KHGFLNLGQI ; FGDYYHFWHR ; GVTKRSLSPH ; RPRHSRLQRE ; PQVQWLEQQV ; 150: AKRRTKRDVY ; QEPTDPKFPQ ; QWYLSGVTQR ; DLNVKAAWAQ ; GYTGHGIVVS ; 200: ILDDGIEKNH ; PDLAGNYDPG ; ASFDVNDQDP ; DPQPRYTQMN ; DNRHGTRCAG ; 250: EVAAVANNGV ; CGVGVAYNAR ; IGGVRMLDGE ; VTDAVEARSL ; GLNPNHIHIY ; 300: SASWGPEDDG ; KTVDGPARLA ; EEAFFRGVSQ ; GRGGLGSIFV ; WASGNGGREH ; 350: DSCNCDGYTN ; SIYTLSISSA ; TQFGNVPWYS ; EACSSTLATT ; YSSGNQNEKQ ; 400: IVTTDLRQKC ; TESHTGTSAS ; APLAAGIIAL ; TLEANKNLTW ; RDMQHLVVQT ; 450: SKPAHLNAND ; WATNGVGRKV ; SHSYGYGLLD ; AGAMVALAQN ; WTTVAPQRKC ; 500: IIDILTEPKD ; IGKRLEVRKT ; VTACLGEPNH ; ITRLEHAQAR ; LTLSYNRRGD ; 550: LAIHLVSPMG ; TRSTLLAARP ; HDYSADGFND ; WAFMTTHSWD ; EDPSGEWVLE ; 600: IENTSEANNY ; GTLTKFTLVL ; YGTAPEGLPV ; PPESSGCKTL ; TSSQACVVCE ; 650: EGFSLHQKSC ; VQHCPPGFAP ; QVLDTHYSTE ; NDVETIRASV ; CAPCHASCAT ; 700: CQGPALTDCL ; SCPSHASLDP ; VEQTCSRQSQ ; SSRESPPQQQ ; PPRLPPEVEA ; 750: GQRLRAGLLP ; SHLPEVVAGL ; SCAFIVLVFV ; TVFLVLQLRS ; GFSFRGVKVY ; 794: TMDRGLISYK ; GLPPEAWQEE ; CPSDSEEDEG ; RGERTAFIKD ; QSAL
Sequence Length	794
String	P09958
Sub Unit	Interacts with FLNA (By similarity). Binds to PACS1 which mediates TGN localization and connection to clathrin adapters.

Uniprot	P09958
Gene Name	FURIN
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:5045
Unigene	Hs.513153

Reference	1. "Structural homology between the human fur gene product and the subtilisin-like protease encoded by yeast KEX2." van den Ouweland A.M.W., van Duijnhoven H.L.P., Keizer G.D., Dorssers L.C.J., van de Ven W.J.M. Nucleic Acids Res.18:664-664(1990) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] tissue: Blood. 2. "Expression of a human proprotein processing enzyme: correct cleavage of the von Willebrand factor precursor at a paired basic amino acid site." Wise R.J., Barr P.J., Wong P.A., Kiefer M.C., Brake A.J., Kaufman R.J. Proc. Natl. Acad. Sci. U.S.A.87:9378-9382(1990) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 3. "cDNA and gene structure for a human subtilisin-like protease with cleavage specificity for paired basic amino acid residues." Barr P.J., Mason O.B., Landsberg K.E., Wong P.A., Kiefer M.C., Brake A.J. DNA Cell Biol.10:319-328(1991) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] tissue: Lung. 5. "Nucleotide sequence analysis of the human fur gene." Van den Ouweland A.M.W., van Groningen J.J.M., Roebrock A.J.M., Onnekink C., Van de Ven W.J.M. Nucleic Acids Res.17:7101-7102(1989) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-280 6. "Evolutionary conserved close linkage of the c-fes/fps proto-oncogene and genetic sequences encoding a receptor-like protein." Roebroek A.J.M., Schalken J.A., Leunissen J.A.M., Onnekink C., Bloemers H.P.J., van de Ven W.J.M. EMBO J.5:2197-2202(1986) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 296-794 7. "A mutation of furin causes the lack of precursor-processing activity in human colon carcinoma LoVo cells." Takahashi S., Kasai K., Hatsuzawa K., Kitamura N., Misumi Y., Ikehara Y., Murakami K., Nakayama K. Biochem. Biophys. Res. Commun.195:1019-1026(1993) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 402-428;FUNCTION tissue: Colon carcinoma. 8. "A second mutant allele of furin in the processing-incompetent cell line, LoVo. Evidence for involvement of the homo B domain in autocatalytic activation." Takahashi S., Nakagawa T., Kasai K., Banno T., Duguay S.J., Van de Ven W.J.M., Murakami K., Nakayama K. J. Biol. Chem.270:26565-26569(1995) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 527-553;VARIANT ARG-547 tissue: Colon carcinoma. 9. "Activation of human furin precursor processing endoprotease occurs by an intramolecular autoproteolytic cleavage." Leduc R., Molloy S.S., Thorne B.A., Thomas G. J. Biol. Chem.267:14304-14308(1992) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC PROCESSING 10. "Homology modelling of the catalytic domain of human furin. A model for the eukaryotic subtilisin-like proprotein convertases." Siezen R.J., Creemers J.W.M., van de Ven W.J.M. Eur. J. Biochem.222:255-266(1994) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: 3D-STRUCTURE MODELING OF CATALYTIC DOMAIN 11. "Intracellular trafficking of furin is modulated by the phosphorylation state of a casein kinase II site in its cytoplasmic tail." Jones B.G., Thomas L., Molloy S.S., Thulin C.D., Fry M.D., Walsh K.A., Thomas G. EMBO J.14:5869-5883(1995) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-773 AND SER-775 12. "PACS-1 binding to adaptors is required for acidic cluster motif-mediated protein traffic." Crump C.M., Xiang Y., Thomas L., Gu F., Austin C., Tooze S.A., Thomas G. EMBO J.20:2191-2201(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PACS1

Have you used this product?

Rate it now..!!

Login to Review

SKU	Supplier No.	Size	Your price	Quantity
BHE13804290	E9700h	96T	$736		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2024 Biohippo. All rights reserved.