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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Frizzled-4

SKU : BHE13805179

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E9388h
Alternative Names	FzE4 ; CD344
Categories	Elisa
Function	Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes. Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP). In retina, it can be both activated by Wnt protein-binding, but also by a Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
Specificity	Natural and recombinant Human Frizzled-4
Subcellular Location	Membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein
Detection Range	0.78-50ng/mL
Entryname	FZD4_HUMAN
Method Type	Sandwich
Platform	PF01534
Protein Name	Frizzled-4
Sensitivity	0.22ng/mL
Sequence	50: MAWRGAGPSV ; PGAPGGVGLS ; LGLLLQLLLL ; LGPARGFGDE ; EERRCDPIRI ; 100: SMCQNLGYNV ; TKMPNLVGHE ; LQTDAELQLT ; TFTPLIQYGC ; SSQLQFFLCS ; 150: VYVPMCTEKI ; NIPIGPCGGM ; CLSVKRRCEP ; VLKEFGFAWP ; ESLNCSKFPP ; 200: QNDHNHMCME ; GPGDEEVPLP ; HKTPIQPGEE ; CHSVGTNSDQ ; YIWVKRSLNC ; 250: VLKCGYDAGL ; YSRSAKEFTD ; IWMAVWASLC ; FISTAFTVLT ; FLIDSSRFSY ; 300: PERPIIFLSM ; CYNIYSIAYI ; VRLTVGRERI ; SCDFEEAAEP ; VLIQEGLKNT ; 350: GCAIIFLLMY ; FFGMASSIWW ; VILTLTWFLA ; AGLKWGHEAI ; EMHSSYFHIA ; 400: AWAIPAVKTI ; VILIMRLVDA ; DELTGLCYVG ; NQNLDALTGF ; VVAPLFTYLV ; 450: IGTLFIAAGL ; VALFKIRSNL ; QKDGTKTDKL ; ERLMVKIGVF ; SVLYTVPATC ; 500: VIACYFYEIS ; NWALFRYSAD ; DSNMAVEMLK ; IFMSLLVGIT ; SGMWIWSAKT ; 537: LHTWQKCSNR ; LVNSGKVKRE ; KRGNGWVKPG ; KGSETVV
Sequence Length	537
String	Q9ULV1
Sub Unit	Interacts with MAGI3 and norrin (NDP). Component of a complex, at least composed of TSPAN12, FZD4 and norrin (NDP).

Uniprot	Q9ULV1
Gene Name	FZD4
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:8322
Unigene	Hs.591968

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SKU	Supplier No.	Size	Your price	Quantity
BHE13805179	E9388h	96T	$736		Add to Cart

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