Forkhead box protein O1A ; Forkhead in rhabdomyosarcoma ; FKHR ; FOXO1A
Categories
Elisa
Function
Transcription factor which acts as a regulator of cell responses to oxidative stress. In the presence of KIRT1, mediates down-regulation of cyclin D1 and up-regulation of CDKN1B levels which are required for cell transition from proliferative growth to quiescence (By similarity). Triggers death of postmitotic neurons when phosphorylated by CDK1. Activates transcription of PMAIP1.
Specificity
Natural and recombinant Human Forkhead box protein O1
Subcellular Location
Cytoplasm Nucleus Shuttles between cytoplasm and nucleus. Translocates to the nucleus upon oxidative stress induced phosphorylation at Ser-212 by STK4/MST1.
Interacts with LRPPRC (By similarity). Interacts with SIRT1 and this interaction requires the presence of KRIT1 (By similarity). Interacts with NLK (By similarity). Binds to CDK1 and 14-3-3 proteins.