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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Focal adhesion kinase 1

SKU : BHE13803906

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1178h
Alternative Names	Focal adhesion kinase-related nonkinase ; FRNK ; Protein phosphatase 1 regulatory subunit 71 ; PPP1R71 ; Protein-tyrosine kinase 2 ; p125FAK ; pp125FAK ; FAK ; FAK1
Categories	Elisa
Function	Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Microtubule-induced dephosphorylation at Tyr-397 is crucial for the induction of focal adhesion disassembly. Plays a potential role in oncogenic transformations resulting in increased kinase activity.
Specificity	Natural and recombinant Human Focal adhesion kinase 1
Subcellular Location	Cell junction focal adhesion Cell membrane Peripheral membrane protein Cytoplasmic side Constituent of focal adhesions.
Detection Range	1.56-100ng/mL
Entryname	FAK1_HUMAN
Method Type	Sandwich
Platform	PF00373
Protein Name	Focal adhesion kinase 1
Sensitivity	0.098ng/mL
Sequence	50: MAAAYLDPNL ; NHTPNSSTKT ; HLGTGMERSP ; GAMERVLKVF ; HYFESNSEPT ; 100: TWASIIRHGD ; ATDVRGIIQK ; IVDSHKVKHV ; ACYGFRLSHL ; RSEEVHWLHV ; 150: DMGVSSVREK ; YELAHPPEEW ; KYELRIRYLP ; KGFLNQFTED ; KPTLNFFYQQ ; 200: VKSDYMLEIA ; DQVDQEIALK ; LGCLEIRRSY ; WEMRGNALEK ; KSNYEVLEKD ; 250: VGLKRFFPKS ; LLDSVKAKTL ; RKLIQQTFRQ ; FANLNREESI ; LKFFEILSPV ; 300: YRFDKECFKC ; ALGSSWIISV ; ELAIGPEEGI ; SYLTDKGCNP ; THLADFTQVQ ; 350: TIQYSNSEDK ; DRKGMLQLKI ; AGAPEPLTVT ; APSLTIAENM ; ADLIDGYCRL ; 400: VNGTSQSFII ; RPQKEGERAL ; PSIPKLANSE ; KQGMRTHAVS ; VSETDDYAEI ; 450: IDEEDTYTMP ; STRDYEIQRE ; RIELGRCIGE ; GQFGDVHQGI ; YMSPENPALA ; 500: VAIKTCKNCT ; SDSVREKFLQ ; EALTMRQFDH ; PHIVKLIGVI ; TENPVWIIME ; 550: LCTLGELRSF ; LQVRKYSLDL ; ASLILYAYQL ; STALAYLESK ; RFVHRDIAAR ; 600: NVLVSSNDCV ; KLGDFGLSRY ; MEDSTYYKAS ; KGKLPIKWMA ; PESINFRRFT ; 650: SASDVWMFGV ; CMWEILMHGV ; KPFQGVKNND ; VIGRIENGER ; LPMPPNCPPT ; 700: LYSLMTKCWA ; YDPSRRPRFT ; ELKAQLSTIL ; EEEKAQQEER ; MRMESRRQAT ; 750: VSWDSGGSDE ; APPKPSRPGY ; PSPRSSEGFY ; PSPQHMVQTN ; HYQVSGYPGS ; 800: HGITAMAGSI ; YPGQASLLDQ ; TDSWNHRPQE ; IAMWQPNVED ; STVLDLRGIG ; 850: QVLPTHLMEE ; RLIRQQQEME ; EDQRWLEKEE ; RFLKPDVRLS ; RGSIDREDGS ; 900: LQGPIGNQHI ; YQPVGKPDPA ; APPKKPPRPG ; APGHLGSLAS ; LSSPADSYNE ; 950: GVKLQPQEIS ; PPPTANLDRS ; NDKVYENVTG ; LVKAVIEMSS ; KIQPAPPEEY ; 1000: VPMVKEVGLA ; LRTLLATVDE ; TIPLLPASTH ; REIEMAQKLL ; NSDLGELINK ; 1050: MKLAQQYVMT ; SLQQEYKKQM ; LTAAHALAVD ; AKNLLDVIDQ ; ARLKMLGQTR ; 1052: PH
Sequence Length	1052
String	Q05397
Sub Unit	Interacts with CAS family members. Interacts with GIT1. Interacts with SORBS1. Interacts with BCAR3. Interacts with RGNEF. Interacts with SHB. Interacts with PXN (By similarity). Component of a complex that contains at least FER, CTTN and PTK2/FAK. Interacts with BMX. Interacts with TGFB1I1. Interacts with STEAP4. Interacts with ZFYVE21. Interacts with ESR1. Interacts with PIK3R1 or PIK3R2. Interacts with SRC. Interacts with EPHA2 (inactive form); participates to EPHA2 downstream signaling. Interacts with CD4; this interaction requires the presence of HIV-1 gp120. Interacts with EPHA1 (kinase activity-dependent).

Uniprot	Q05397
Gene Name	PTK2
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:5747
Unigene	Hs.395482

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SKU	Supplier No.	Size	Your price	Quantity
BHE13803906	E1178h	96T	$536		Add to Cart

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