Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin. Diminishes HSPG (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation.
Specificity
Natural and recombinant Human Extracellular sulfatase Sulf-1
Subcellular Location
Endoplasmic reticulum Golgi apparatus Golgi stack Cell surface Also localized on the cell surface.