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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Eukaryotic translation initiation factor 5A-1

SKU : BHE13805575

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2696h
Alternative Names	Eukaryotic initiation factor 5A isoform 1 ; eIF-5A ; Rev-binding factor ; eIF-4D
Categories	Elisa
Function	mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF-alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation. Also described as a cellular cofactor of human T-cell leukemia virus type I (HTLV-1) Rex protein and of human immunodeficiency virus type 1 (HIV-1) Rev protein, essential for mRNA export of retroviral transcripts.
Specificity	Natural and recombinant Human Eukaryotic translation initiation factor 5A-1
Subcellular Location	Cytoplasm Nucleus Endoplasmic reticulum membrane Peripheral membrane protein Cytoplasmic side Nucleus nuclear pore complex Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions.
Detection Range	0.312-20ng/mL
Entryname	IF5A1_HUMAN
Method Type	Sandwich
Platform	PF01287
Protein Name	Eukaryotic translation initiation factor 5A-1
Sensitivity	0.163ng/mL
Sequence	50: MADDLDFETG ; DAGASATFPM ; QCSALRKNGF ; VVLKGRPCKI ; VEMSTSKTGK ; 100: HGHAKVHLVG ; IDIFTGKKYE ; DICPSTHNMD ; VPNIKRNDFQ ; LIGIQDGYLS ; 150: LLQDSGEVRE ; DLRLPEGDLG ; KEIEQKYDCG ; EEILITVLSA ; MTEEAAVAIK ; 154: AMAK
Sequence Length	154
String	P63241
Sub Unit	Interacts with DHPS, with SDCBP and DOHH. Interacts with HIV-1 protein Rev. Found in a complex with Ran and XPO4. The hypusine modification increases the interaction with XPO4.

Uniprot	P63241
Gene Name	EIF5A
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:1984
Unigene	Hs.104825

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SKU	Supplier No.	Size	Your price	Quantity
BHE13805575	E2696h	96T	$736		Add to Cart

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