ELISA Kit for Human Eukaryotic translation initiation factor 4E-binding protein 1

Mfr.No.	E2693h
Alternative Names	Phosphorylated heat- and acid-stable protein regulated by insulin 1 ; PHAS-I
Categories	Elisa
Function	Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.
Specificity	Natural and recombinant Human Eukaryotic translation initiation factor 4E-binding protein 1
Detection Range	0.78-50ng/mL
Entryname	4EBP1_HUMAN
Method Type	Sandwich
Platform	PF05456
Protein Name	Eukaryotic translation initiation factor 4E-binding protein 1
Sensitivity	0.408ng/mL
Sequence	50: MSGGSSCSQT ; PSRAIPATRR ; VVLGDGVQLP ; PGDYSTTPGG ; TLFSTTPGGT ; 100: RIIYDRKFLM ; ECRNSPVTKT ; PPRDLPTIPG ; VTSPSSDEPP ; MEASQSHLRN ; 118: SPEDKRAGGE ; ESQFEMDI
Sequence Length	118
String	Q13541
Sub Unit	Nonphosphorylated EIF4EBP1 competes with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) or mTORC1 phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. Interacts with RPTOR.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13800297	E2693h	96T	$736		Add to Cart