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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Estrogen receptor beta

SKU : BHE13803922

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2300h
Alternative Names	Nuclear receptor subfamily 3 group A member 2 ; ESTRB ; NR3A2
Categories	Elisa
Function	Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.
Specificity	Natural and recombinant Human Estrogen receptor beta
Subcellular Location	Nucleus
Detection Range	0.312-20ng/mL
Entryname	ESR2_HUMAN
Method Type	Sandwich
Platform	PF12497
Protein Name	Estrogen receptor beta
Sensitivity	0.132ng/mL
Sequence	50: MDIKNSPSSL ; NSPSSYNCSQ ; SILPLEHGSI ; YIPSSYVDSH ; HEYPAMTFYS ; 100: PAVMNYSIPS ; NVTNLEGGPG ; RQTTSPNVLW ; PTPGHLSPLV ; VHRQLSHLYA ; 150: EPQKSPWCEA ; RSLEHTLPVN ; RETLKRKVSG ; NRCASPVTGP ; GSKRDAHFCA ; 200: VCSDYASGYH ; YGVWSCEGCK ; AFFKRSIQGH ; NDYICPATNQ ; CTIDKNRRKS ; 250: CQACRLRKCY ; EVGMVKCGSR ; RERCGYRLVR ; RQRSADEQLH ; CAGKAKRSGG ; 300: HAPRVRELLL ; DALSPEQLVL ; TLLEAEPPHV ; LISRPSAPFT ; EASMMMSLTK ; 350: LADKELVHMI ; SWAKKIPGFV ; ELSLFDQVRL ; LESCWMEVLM ; MGLMWRSIDH ; 400: PGKLIFAPDL ; VLDRDEGKCV ; EGILEIFDML ; LATTSRFREL ; KLQHKEYLCV ; 450: KAMILLNSSM ; YPLVTATQDA ; DSSRKLAHLL ; NAVTDALVWV ; IAKSGISSQQ ; 500: QSMRLANLLM ; LLSHVRHASN ; KGMEHLLNMK ; CKNVVPVYDL ; LLEMLNAHVL ; 530: RGCKSSITGS ; ECSPAEDSKS ; KEGSQNPQSQ ;
Sequence Length	530
String	Q92731
Sub Unit	Binds DNA as a homodimer. Can form a heterodimer with ESR1. Interacts with NCOA3, NCOA5 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts with PELP1 and UBE1C. Isoform beta-2/cx preferentially forms a hetereodimer with ESR1 rather than ESR2 and inhibits DNA-binding by ESR1. Interacts with AKAP13. Interacts with DNTTIP2. Interacts with isoform 4 of TXNRD1. Interacts with CCDC62 in the presence of estradiol/E2; this interaction seems to enhance the transcription of target genes, including cyclin-D1/CCND1 AP-1 promoter. Interacts with DYX1C1 (By similarity). Interacts with PRMT2.

Uniprot	Q92731
Gene Name	ESR2
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:2100
Unigene	Hs.660607

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SKU	Supplier No.	Size	Your price	Quantity
BHE13803922	E2300h	96T	$736		Add to Cart

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