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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Endoplasmic reticulum aminopeptidase 1

SKU : BHE13803692

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E12631h
Alternative Names	ARTS-1 ; Adipocyte-derived leucine aminopeptidase ; A-LAP ; Aminopeptidase PILS ; Puromycin-insensitive leucyl-specific aminopeptidase ; PILS-AP ; Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator ; APPILS ; ARTS1 ; KIAA0525 ; UNQ584/PRO1154
Categories	Elisa
Function	Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney.
Specificity	Natural and recombinant Human Endoplasmic reticulum aminopeptidase 1
Subcellular Location	Endoplasmic reticulum membrane Single-pass type II membrane protein
Detection Range	0.156-10ng/mL
Entryname	ERAP1_HUMAN
Method Type	Sandwich
Platform	PF11838
Protein Name	Endoplasmic reticulum aminopeptidase 1
Sensitivity	0.085ng/mL
Sequence	50: MVFLPLKWSL ; ATMSFLLSSL ; LALLTVSTPS ; WCQSTEASPK ; RSDGTPFPWN ; 100: KIRLPEYVIP ; VHYDLLIHAN ; LTTLTFWGTT ; KVEITASQPT ; STIILHSHHL ; 150: QISRATLRKG ; AGERLSEEPL ; QVLEHPRQEQ ; IALLAPEPLL ; VGLPYTVVIH ; 200: YAGNLSETFH ; GFYKSTYRTK ; EGELRILAST ; QFEPTAARMA ; FPCFDEPAFK ; 250: ASFSIKIRRE ; PRHLAISNMP ; LVKSVTVAEG ; LIEDHFDVTV ; KMSTYLVAFI ; 300: ISDFESVSKI ; TKSGVKVSVY ; AVPDKINQAD ; YALDAAVTLL ; EFYEDYFSIP ; 350: YPLPKQDLAA ; IPDFQSGAME ; NWGLTTYRES ; ALLFDAEKSS ; ASSKLGITMT ; 400: VAHELAHQWF ; GNLVTMEWWN ; DLWLNEGFAK ; FMEFVSVSVT ; HPELKVGDYF ; 450: FGKCFDAMEV ; DALNSSHPVS ; TPVENPAQIR ; EMFDDVSYDK ; GACILNMLRE ; 500: YLSADAFKSG ; IVQYLQKHSY ; KNTKNEDLWD ; SMASICPTDG ; VKGMDGFCSR ; 550: SQHSSSSSHW ; HQEGVDVKTM ; MNTWTLQKGF ; PLITITVRGR ; NVHMKQEHYM ; 600: KGSDGAPDTG ; YLWHVPLTFI ; TSKSDMVHRF ; LLKTKTDVLI ; LPEEVEWIKF ; 650: NVGMNGYYIV ; HYEDDGWDSL ; TGLLKGTHTA ; VSSNDRASLI ; NNAFQLVSIG ; 700: KLSIEKALDL ; SLYLKHETEI ; MPVFQGLNEL ; IPMYKLMEKR ; DMNEVETQFK ; 750: AFLIRLLRDL ; IDKQTWTDEG ; SVSERMLRSQ ; LLLLACVHNY ; QPCVQRAEGY ; 800: FRKWKESNGN ; LSLPVDVTLA ; VFAVGAQSTE ; GWDFLYSKYQ ; FSLSSTEKSQ ; 850: IEFALCRTQN ; KEKLQWLLDE ; SFKGDKIKTQ ; EFPQILTLIG ; RNPVGYPLAW ; 900: QFLRKNWNKL ; VQKFELGSSS ; IAHMVMGTTN ; QFSTRTRLEE ; VKGFFSSLKE ; 941: NGSQLRCVQQ ; TIETIEENIG ; WMDKNFDKIR ; VWLQSEKLER ; M
Sequence Length	941
String	Q9NZ08
Sub Unit	Monomer. May also exist as a heterodimer; with ERAP2. Interacts with RBMX.

Uniprot	Q9NZ08
Gene Name	ERAP1
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:51752
Unigene	Hs.716426

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SKU	Supplier No.	Size	Your price	Quantity
BHE13803692	E12631h	96T	$736		Add to Cart

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