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Home / Assay Kits / ELISA Kits

ELISA Kit for Human E3 ubiquitin-protein ligase Mdm2

SKU : BHE13806308

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E12872h
Alternative Names	Double minute 2 protein ; Hdm2 ; Oncoprotein Mdm2 ; RING-type E3 ubiquitin transferase Mdm2 ; p53-binding protein Mdm2
Categories	Elisa
Function	E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as an ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways.
Specificity	Natural and recombinant Human E3 ubiquitin-protein ligase Mdm2
Subcellular Location	Nucleus nucleoplasm Cytoplasm Nucleus nucleolus Expressed predominantly in the nucleoplasm. Interaction with ARF(P14) results in the localization of both proteins to the nucleolus. The nucleolar localization signals in both ARF(P14) and MDM2 may be necessary to allow efficient nucleolar localization of both proteins. Colocalizes with RASSF1 isoform A in the nucleus.
Entryname	MDM2_HUMAN
Platform	PF02201
Protein Name	E3 ubiquitin-protein ligase Mdm2
Sequence	50: MCNTNMSVPT ; DGAVTTSQIP ; ASEQETLVRP ; KPLLLKLLKS ; VGAQKDTYTM ; 100: KEVLFYLGQY ; IMTKRLYDEK ; QQHIVYCSND ; LLGDLFGVPS ; FSVKEHRKIY ; 150: TMIYRNLVVV ; NQQESSDSGT ; SVSENRCHLE ; GGSDQKDLVQ ; ELQEEKPSSS ; 200: HLVSRPSTSS ; RRRAISETEE ; NSDELSGERQ ; RKRHKSDSIS ; LSFDESLALC ; 250: VIREICCERS ; SSSESTGTPS ; NPDLDAGVSE ; HSGDWLDQDS ; VSDQFSVEFE ; 300: VESLDSEDYS ; LSEEGQELSD ; EDDEVYQVTV ; YQAGESDTDS ; FEEDPEISLA ; 350: DYWKCTSCNE ; MNPPLPSHCN ; RCWALRENWL ; PEDKGKDKGE ; ISEKAKLENS ; 400: TQAEEGFDVP ; DCKKTIVNDS ; RESCVEENDD ; KITQASQSQE ; SEDYSQPSTS ; 450: SSIIYSSQED ; VKEFEREETQ ; DKEESVESSL ; PLNAIEPCVI ; CQGRPKNGCI ; 491: VHGKTGHLMA ; CFTCAKKLKK ; RNKPCPVCRQ ; PIQMIVLTYF ; P
Sequence Length	491
String	Q00987
Sub Unit	Binds p53/TP53, TP73/p73, ARF/P14, PML, RBL5 and RP11, and specifically to RNA. Can interact with RB1, E1A-associated protein EP300 and the E2F1 transcription factor. Forms a ternary complex with p53/TP53 and WWOX. Interacts with CDKN2AIP, MTBP, RFWD3, TBRG1, USP7, PYHIN1, UBXN6, and RBBP6. Isoform Mdm2-F does not interact with p53/TP53. Interacts with and ubiquitinates HIV-1 Tat. Interacts with ARRB1 and ARRB2. Interacts (isoform 2) with PSMA3. Found in a trimeric complex with MDM2, MDM4 and UPB2. Interacts with USP2 (via N-terminus and C-terminus). Interacts with MDM4. Part of a complex with MDM2, DAXX, RASSF1 and USP7. Part of a complex with DAXX, MDM2 and USP7. Interacts directly with DAXX and USP7. Interacts (via C-terminus) with RASSF1 isoform A (via N-terminus); the interaction is independent of TP53. Interacts with APEX1; leading to its ubiquitination and degradation. Interacts with RYBP; this inhibits ubiquitination of TP53. Identified in a complex with RYBP and p53/TP53. Also component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in regulating p53/TP53 stabilization and activity. Binds directly both p53/TP53 and TRIM28. Component of the TRIM28/KAP1-ERBB4-MDM2 complex involved in connecting growth factor responses with DNA damage. Interacts directly with both MDM2 and ERBB4 in the complex.

Uniprot	Q00987
Gene Name	MDM2
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:4193
Unigene	Hs.484551

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SKU	Supplier No.	Size	Your price	Quantity
BHE13806308	E12872h	96T	$736		Add to Cart

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