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ELISA Kit for Human E3 ubiquitin-protein ligase HUWE1

SKU : BHE13805486

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2369h
Alternative Names	ARF-binding protein 1 ; ARF-BP1 ; HECT ; UBA and WWE domain-containing protein 1 ; HECT-type E3 ubiquitin transferase HUWE1 ; Homologous to E6AP carboxyl terminus homologous protein 9 ; HectH9 ; Large structure of UREB1 ; LASU1 ; Mcl-1 ubiquitin ligase E3 ; Mule ; Upstream regulatory element-binding protein 1 ; URE-B1 ; KIAA0312 ; KIAA1578 ; UREB1 ; HSPC272
Categories	Elisa
Function	E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair. Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Binds to an upstream initiator-like sequence in the preprodynorphin gene. Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN. May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation.
Specificity	Natural and recombinant Human E3 ubiquitin-protein ligase HUWE1
Subcellular Location	Cytoplasm Nucleus Mainly expressed in the cytoplasm of most tissues, except in the nucleus of spermatogonia, primary spermatocytes and neuronal cells (By similarity). Predominantly cytosolic or perinuclear in some colorectal carcinoma cells.
Detection Range	0.156-10ng/mL
Entryname	HUWE1_HUMAN
Method Type	Sandwich
Platform	PF14377
Protein Name	E3 ubiquitin-protein ligase HUWE1
Sensitivity	0.067ng/mL
Sequence	50: MKVDRTKLKK ; TPTEAPADCR ; ALIDKLKVCN ; DEQLLLELQQ ; IKTWNIGKCE ; 100: LYHWVDLLDR ; FDGILADAGQ ; TVENMSWMLV ; CDRPEREQLK ; MLLLAVLNFT ; 150: ALLIEYSFSR ; HLYSSIEHLT ; TLLASSDMQV ; VLAVLNLLYV ; FSKRSNYITR ; 200: LGSDKRTPLL ; TRLQHLAESW ; GGKENGFGLA ; ECCRDLHMMK ; YPPSATTLHF ; 250: EFYADPGAEV ; KIEKRTTSNT ; LHYIHIEQLD ; KISESPSEIM ; ESLTKMYSIP ; 300: KDKQMLLFTH ; IRLAHGFSNH ; RKRLQAVQAR ; LHAISILVYS ; NALQESANSI ; 350: LYNGLIEELV ; DVLQITDKQL ; MEIKAASLRT ; LTSIVHLERT ; PKLSSIIDCT ; 400: GTASYHGFLP ; VLVRNCIQAM ; IDPSMDPYPH ; QFATALFSFL ; YHLASYDAGG ; 450: EALVSCGMME ; ALLKVIKFLG ; DEQDQITFVT ; RAVRVVDLIT ; NLDMAAFQSH ; 500: SGLSIFIYRL ; EHEVDLCRKE ; CPFVIKPKIQ ; RPNTTQEGEE ; METDMDGVQC ; 550: IPQRAALLKS ; MLNFLKKAIQ ; DPAFSDGIRH ; VMDGSLPTSL ; KHIISNAEYY ; 600: GPSLFLLATE ; VVTVFVFQEP ; SLLSSLQDNG ; LTDVMLHALL ; IKDVPATREV ; 650: LGSLPNVFSA ; LCLNARGLQS ; FVQCQPFERL ; FKVLLSPDYL ; PAMRRRRSSD ; 700: PLGDTASNLG ; SAVDELMRHQ ; PTLKTDATTA ; IIKLLEEICN ; LGRDPKYICQ ; 750: KPSIQKADGT ; ATAPPPRSNH ; AAEEASSEDE ; EEEEVQAMQS ; FNSTQQNETE ; 800: PNQQVVGTEE ; RIPIPLMDYI ; LNVMKFVESI ; LSNNTTDDHC ; QEFVNQKGLL ; 850: PLVTILGLPN ; LPIDFPTSAA ; CQAVAGVCKS ; ILTLSHEPKV ; LQEGLLQLDS ; 900: ILSSLEPLHR ; PIESPGGSVL ; LRELACAGNV ; ADATLSAQAT ; PLLHALTAAH ; 950: AYIMMFVHTC ; RVGQSEIRSI ; SVNQWGSQLG ; LSVLSKLSQL ; YCSLVWESTV ; 1000: LLSLCTPNSL ; PSGCEFGQAD ; MQKLVPKDEK ; AGTTQGGKRS ; DGEQDGAAGS ; 1050: MDASTQGLLE ; GIGLDGDTLA ; PMETDEPTAS ; DSKGKSKITP ; AMAARIKQIK ; 1100: PLLSASSRLG ; RALAELFGLL ; VKLCVGSPVR ; QRRSHHAAST ; TTAPTPAARS ; 1150: TASALTKLLT ; KGLSWQPPPY ; TPTPRFRLTF ; FICSVGFTSP ; MLFDERKYPY ; 1200: HLMLQKFLCS ; GGHNALFETF ; NWALSMGGKV ; PVSEGLEHSD ; LPDGTGEFLD ; 1250: AWLMLVEKMV ; NPTTVLESPH ; SLPAKLPGGV ; QNFPQFSALR ; FLVVTQKAAF ; 1300: TCIKNLWNRK ; PLKVYGGRMA ; ESMLAILCHI ; LRGEPVIRER ; LSKEKEGSRG ; 1350: EEDTGQEEGG ; SRREPQVNQQ ; QLQQLMDMGF ; TREHAMEALL ; NTSTMEQATE ; 1400: YLLTHPPPIM ; GGVVRDLSMS ; EEDQMMRAIA ; MSLGQDIPMD ; QRAESPEEVA ; 1450: CRKEEEERKA ; REKQEEEEAK ; CLEKFQDADP ; LEQDELHTFT ; DTMLPGCFHL ; 1500: LDELPDTVYR ; VCDLIMTAIK ; RNGADYRDMI ; LKQVVNQVWE ; AADVLIKAAL ; 1550: PLTTSDTKTV ; SEWISQMATL ; PQASNLATRI ; LLLTLLFEEL ; KLPCAWVVES ; 1600: SGILNVLIKL ; LEVVQPCLQA ; AKEQKEVQTP ; KWITPVLLLI ; DFYEKTAISS ; 1650: KRRAQMTKYL ; QSNSNNWRWF ; DDRSGRWCSY ; SASNNSTIDS ; AWKSGETSVR ; 1700: FTAGRRRYTV ; QFTTMVQVNE ; ETGNRRPVML ; TLLRVPRLNK ; NSKNSNGQEL ; 1750: EKTLEESKEM ; DIKRKENKGN ; DTPLALESTN ; TEKETSLEET ; KIGEILIQGL ; 1800: TEDMVTVLIR ; ACVSMLGVPV ; DPDTLHATLR ; LCLRLTRDHK ; YAMMFAELKS ; 1850: TRMILNLTQS ; SGFNGFTPLV ; TLLLRHIIED ; PCTLRHTMEK ; VVRSAATSGA ; 1900: GSTTSGVVSG ; SLGSREINYI ; LRVLGPAACR ; NPDIFTEVAN ; CCIRIALPAP ; 1950: RGSGTASDDE ; FENLRIKGPN ; AVQLVKTTPL ; KPSPLPVIPD ; TIKEVIYDML ; 2000: NALAAYHAPE ; EADKSDPKPG ; VMTQEVGQLL ; QDMGDDVYQQ ; YRSLTRQSSD ; 2050: FDTQSGFSIN ; SQVFAADGAS ; TETSASGTSQ ; GEASTPEESR ; DGKKDKEGDR ; 2100: ASEEGKQKGK ; GSKPLMPTST ; ILRLLAELVR ; SYVGIATLIA ; NYSYTVGQSE ; 2150: LIKEDCSVLA ; FVLDHLLPHT ; QNAEDKDTPA ; LARLFLASLA ; AAGSGTDAQV ; 2200: ALVNEVKAAL ; GRALAMAEST ; EKHARLQAVM ; CIISTIMESC ; PSTSSFYSSA ; 2250: TAKTQHNGMN ; NIIRLFLKKG ; LVNDLARVPH ; SLDLSSPNMA ; NTVNAALKPL ; 2300: ETLSRIVNQP ; SSLFGSKSAS ; SKNKSEQDAQ ; GASQDSSSNQ ; QDPGEPGEAE ; 2350: VQEEDHDVTQ ; TEVADGDIMD ; GEAETDSVVI ; AGQPEVLSSQ ; EMQVENELED ; 2400: LIDELLERDG ; GSGNSTIIVS ; RSGEDESQED ; VLMDEAPSNL ; SQASTLQANR ; 2450: EDSMNILDPE ; DEEEHTQEED ; SSGSNEDEDD ; SQDEEEEEEE ; DEEDDQEDDE ; 2500: GEEGDEDDDD ; DGSEMELDED ; YPDMNASPLV ; RFERFDREDD ; LIIEFDNMFS ; 2550: SATDIPPSPG ; NIPTTHPLMV ; RHADHSSLTL ; GSGSSTTRLT ; QGIGRSQRTL ; 2600: RQLTANTGHT ; IHVHYPGNRQ ; PNPPLILQRL ; LGPSAAADIL ; QLSSSLPLQS ; 2650: RGRARLLVGN ; DDVHIIARSD ; DELLDDFFHD ; QSTATSQAGT ; LSSIPTALTR ; 2700: WTEECKVLDA ; ESMHDCVSVV ; KVSIVNHLEF ; LRDEELEERR ; EKRRKQLAEE ; 2750: ETKITDKGKE ; DKENRDQSAQ ; CTASKSNDST ; EQNLSDGTPM ; PDSYPTTPSS ; 2800: TDAATSESKE ; TLGTLQSSQQ ; QPTLPTPPAL ; GEVPQELQSP ; AGEGGSSTQL ; 2850: LMPVEPEELG ; PTRPSGEAET ; TQMELSPAPT ; ITSLSPERAE ; DSDALTAVSS ; 2900: QLEGSPMDTS ; SLASCTLEEA ; VGDTSAAGSS ; EQPRAGSSTP ; GDAPPAVAEV ; 2950: QGRSDGSGES ; AQPPEDSSPP ; ASSESSSTRD ; SAVAISGADS ; RGILEEPLPS ; 3000: TSSEEEDPLA ; GISLPEGVDP ; SFLAALPDDI ; RREVLQNQLG ; IRPPTRTAPS ; 3050: TNSSAPAVVG ; NPGVTEVSPE ; FLAALPPAIQ ; EEVLAQQRAE ; QQRRELAQNA ; 3100: SSDTPMDPVT ; FIQTLPSDLR ; RSVLEDMEDS ; VLAVMPPDIA ; AEAQALRREQ ; 3150: EARQRQLMHE ; RLFGHSSTSA ; LSAILRSPAF ; TSRLSGNRGV ; QYTRLAVQRG ; 3200: GTFQMGGSSS ; HNRPSGSNVD ; TLLRLRGRLL ; LDHEALSCLL ; VLLFVDEPKL ; 3250: NTSRLHRVLR ; NLCYHAQTRH ; WVIRSLLSIL ; QRSSESELCI ; ETPKLTTSEE ; 3300: KGKKSSKSCG ; SSSHENRPLD ; LLHKMESKSS ; NQLSWLSVSM ; DAALGCRTNI ; 3350: FQIQRSGGRK ; HTEKHASGGS ; TVHIHPQAAP ; VVCRHVLDTL ; IQLAKVFPSH ; 3400: FTQQRTKETN ; CESDRERGNK ; ACSPCSSQSS ; SSGICTDFWD ; LLVKLDNMNV ; 3450: SRKGKNSVKS ; VPVSAGGEGE ; TSPYSLEASP ; LGQLMNMLSH ; PVIRRSSLLT ; 3500: EKLLRLLSLI ; SIALPENKVS ; EAQANSGSGA ; SSTTTATSTT ; STTTTTAAST ; 3550: TPTPPTAPTP ; VTSAPALVAA ; TAISTIVVAA ; STTVTTPTTA ; TTTVSISPTT ; 3600: KGSKSPAKVS ; DGGSSSTDFK ; MVSSGLTENQ ; LQLSVEVLTS ; HSCSEEGLED ; 3650: AANVLLQLSR ; GDSGTRDTVL ; KLLLNGARHL ; GYTLCKQIGT ; LLAELREYNL ; 3700: EQQRRAQCET ; LSPDGLPEEQ ; PQTTKLKGKM ; QSRFDMAENV ; VIVASQKRPL ; 3750: GGRELQLPSM ; SMLTSKTSTQ ; KFFLRVLQVI ; IQLRDDTRRA ; NKKAKQTGRL ; 3800: GSSGLGSASS ; IQAAVRQLEA ; EADAIIQMVR ; EGQRARRQQQ ; AATSESSQSE ; 3850: ASVRREESPM ; DVDQPSPSAQ ; DTQSIASDGT ; PQGEKEKEER ; PPELPLLSEQ ; 3900: LSLDELWDML ; GECLKELEES ; HDQHAVLVLQ ; PAVEAFFLVH ; ATERESKPPV ; 3950: RDTRESQLAH ; IKDEPPPLSP ; APLTPATPSS ; LDPFFSREPS ; SMHISSSLPP ; 4000: DTQKFLRFAE ; THRTVLNQIL ; RQSTTHLADG ; PFAVLVDYIR ; VLDFDVKRKY ; 4050: FRQELERLDE ; GLRKEDMAVH ; VRRDHVFEDS ; YRELHRKSPE ; EMKNRLYIVF ; 4100: EGEEGQDAGG ; LLREWYMIIS ; REMFNPMYAL ; FRTSPGDRVT ; YTINPSSHCN ; 4150: PNHLSYFKFV ; GRIVAKAVYD ; NRLLECYFTR ; SFYKHILGKS ; VRYTDMESED ; 4200: YHFYQGLVYL ; LENDVSTLGY ; DLTFSTEVQE ; FGVCEVRDLK ; PNGANILVTE ; 4250: ENKKEYVHLV ; CQMRMTGAIR ; KQLAAFLEGF ; YEIIPKRLIS ; IFTEQELELL ; 4300: ISGLPTIDID ; DLKSNTEYHK ; YQSNSIQIQW ; FWRALRSFDQ ; ADRAKFLQFV ; 4350: TGTSKVPLQG ; FAALEGMNGI ; QKFQIHRDDR ; STDRLPSAHT ; CFNQLDLPAY ; 4374: ESFEKLRHML ; LLAIQECSEG ; FGLA
Sequence Length	4374
String	Q7Z6Z7
Sub Unit	Interacts with isoform p14ARF of CDKN2A which strongly inhibits HUWE1 ubiquitin ligase activity. Interacts with MYCN, POLB and CDC6.

Uniprot	Q7Z6Z7
Gene Name	HUWE1
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:10075
Unigene	Hs.136905

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