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Home / Assay Kits / ELISA Kits

ELISA Kit for Human E3 ubiquitin-protein ligase CBL-B

SKU : BHE13801801

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2531h
Alternative Names	Casitas B-lineage lymphoma proto-oncogene b ; RING finger protein 56 ; RING-type E3 ubiquitin transferase CBL-B ; SH3-binding protein CBL-B ; Signal transduction protein CBL-B ; RNF56 ; Nbla00127
Categories	Elisa
Function	E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. May also be involved in EGFR ubiquitination and internalization.
Specificity	Natural and recombinant Human E3 ubiquitin-protein ligase CBL-B
Subcellular Location	Cytoplasm Upon EGF stimulation, associates with endocytic vesicles.
Detection Range	78-5000pg/mL
Entryname	CBLB_HUMAN
Method Type	Sandwich
Platform	PF02262
Protein Name	E3 ubiquitin-protein ligase CBL-B
Sensitivity	25pg/mL
Sequence	50: MANSMNGRNP ; GGRGGNPRKG ; RILGIIDAIQ ; DAVGPPKQAA ; ADRRTVEKTW ; 100: KLMDKVVRLC ; QNPKLQLKNS ; PPYILDILPD ; TYQHLRLILS ; KYDDNQKLAQ ; 150: LSENEYFKIY ; IDSLMKKSKR ; AIRLFKEGKE ; RMYEEQSQDR ; RNLTKLSLIF ; 200: SHMLAEIKAI ; FPNGQFQGDN ; FRITKADAAE ; FWRKFFGDKT ; IVPWKVFRQC ; 250: LHEVHQISSG ; LEAMALKSTI ; DLTCNDYISV ; FEFDIFTRLF ; QPWGSILRNW ; 300: NFLAVTHPGY ; MAFLTYDEVK ; ARLQKYSTKP ; GSYIFRLSCT ; RLGQWAIGYV ; 350: TGDGNILQTI ; PHNKPLFQAL ; IDGSREGFYL ; YPDGRSYNPD ; LTGLCEPTPH ; 400: DHIKVTQEQY ; ELYCEMGSTF ; QLCKICAEND ; KDVKIEPCGH ; LMCTSCLTAW ; 450: QESDGQGCPF ; CRCEIKGTEP ; IIVDPFDPRD ; EGSRCCSIID ; PFGMPMLDLD ; 500: DDDDREESLM ; MNRLANVRKC ; TDRQNSPVTS ; PGSSPLAQRR ; KPQPDPLQIP ; 550: HLSLPPVPPR ; LDLIQKGIVR ; SPCGSPTGSP ; KSSPCMVRKQ ; DKPLPAPPPP ; 600: LRDPPPPPPE ; RPPPIPPDNR ; LSRHIHHVES ; VPSRDPPMPL ; EAWCPRDVFG ; 650: TNQLVGCRLL ; GEGSPKPGIT ; ASSNVNGRHS ; RVGSDPVLMR ; KHRRHDLPLE ; 700: GAKVFSNGHL ; GSEEYDVPPR ; LSPPPPVTTL ; LPSIKCTGPL ; ANSLSEKTRD ; 750: PVEEDDDEYK ; IPSSHPVSLN ; SQPSHCHNVK ; PPVRSCDNGH ; CMLNGTHGPS ; 800: SEKKSNIPDL ; SIYLKGDVFD ; SASDPVPLPP ; ARPPTRDNPK ; HGSSLNRTPS ; 850: DYDLLIPPLG ; EDAFDALPPS ; LPPPPPPARH ; SLIEHSKPPG ; SSSRPSSGQD ; 900: LFLLPSDPFV ; DLASGQVPLP ; PARRLPGENV ; KTNRTSQDYD ; QLPSCSDGSQ ; 950: APARPPKPRP ; RRTAPEIHHR ; KPHGPEAALE ; NVDAKIAKLM ; GEGYAFEEVK ; 982: RALEIAQNNV ; EVARSILREF ; AFPPPVSPRL ; NL
Sequence Length	982
String	Q13191
Sub Unit	Interacts with SH3 domain-containing proteins LCK, CRK and SORBS1. Interacts with LCP2 and ZAP70. May interact with CBL (By similarity). Interacts with SH3 domain-containing proteins VAV1, FYN, FGR, PLCG1, GRB2, CRKL, PIK3R1 and SH3KBP1/CIN85. Identified in heterotrimeric complexes with SH3KBP1/CIN85, CD2AP and ARHGEF7, where one CBLB peptide binds two copies of the other protein. Interacts with poly-ubiquitinated proteins. Dimerization is required for the binding of poly-ubiquitin, but not for the binding of mono-ubiquitin.

Uniprot	Q13191
Gene Name	CBLB
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:868
Unigene	Hs.430589

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SKU	Supplier No.	Size	Your price	Quantity
BHE13801801	E2531h	96T	$736		Add to Cart

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