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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Disks large homolog 4

SKU : BHE13803312

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E12411h
Alternative Names	Postsynaptic density protein 95 ; PSD-95 ; Synapse-associated protein 90 ; SAP-90 ; PSD95
Categories	Elisa
Function	Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ACCN3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.
Specificity	Natural and recombinant Human Disks large homolog 4
Subcellular Location	Cell membrane Peripheral membrane protein Cell junction synapse postsynaptic cell membrane postsynaptic density Cell junction synapse Cell junction synapse synaptosome High levels in postsynaptic density of neurons in the forebrain. Also in presynaptic region of inhibitory synapses formed by cerebellar basket cells on axon hillocks of Purkinje cells.
Detection Range	0.312-20ng/mL
Entryname	DLG4_HUMAN
Method Type	Sandwich
Platform	PF00625
Protein Name	Disks large homolog 4
Sensitivity	0.097ng/mL
Sequence	50: MDCLCIVTTK ; KYRYQDEDTP ; PLEHSPAHLP ; NQANSPPVIV ; NTDTLEAPGY ; 100: ELQVNGTEGE ; MEYEEITLER ; GNSGLGFSIA ; GGTDNPHIGD ; DPSIFITKII ; 150: PGGAAAQDGR ; LRVNDSILFV ; NEVDVREVTH ; SAAVEALKEA ; GSIVRLYVMR ; 200: RKPPAEKVME ; IKLIKGPKGL ; GFSIAGGVGN ; QHIPGDNSIY ; VTKIIEGGAA ; 250: HKDGRLQIGD ; KILAVNSVGL ; EDVMHEDAVA ; ALKNTYDVVY ; LKVAKPSNAY ; 300: LSDSYAPPDI ; TTSYSQHLDN ; EISHSSYLGT ; DYPTAMTPTS ; PRRYSPVAKD ; 350: LLGEEDIPRE ; PRRIVIHRGS ; TGLGFNIVGG ; EDGEGIFISF ; ILAGGPADLS ; 400: GELRKGDQIL ; SVNGVDLRNA ; SHEQAAIALK ; NAGQTVTIIA ; QYKPEEYSRF ; 450: EAKIHDLREQ ; LMNSSLGSGT ; ASLRSNPKRG ; FYIRALFDYD ; KTKDCGFLSQ ; 500: ALSFRFGDVL ; HVIDASDEEW ; WQARRVHSDS ; ETDDIGFIPS ; KRRVERREWS ; 550: RLKAKDWGSS ; SGSQGREDSV ; LSYETVTQME ; VHYARPIIIL ; GPTKDRANDD ; 600: LLSEFPDKFG ; SCVPHTTRPK ; REYEIDGRDY ; HFVSSREKME ; KDIQAHKFIE ; 650: AGQYNSHLYG ; TSVQSVREVA ; EQGKHCILDV ; SANAVRRLQA ; AHLHPIAIFI ; 700: RPRSLENVLE ; INKRITEEQA ; RKAFDRATKL ; EQEFTECFSA ; IVEGDSFEEI ; 724: YHKVKRVIED ; LSGPYIWVPA ; RERL
Sequence Length	724
String	P78352
Sub Unit	Interacts with ANKS1B, KLHL17 and PRR7 (By similarity). Interacts through its PDZ domains with NETO1. Interacts through its first two PDZ domains with GRIN2A, GRIN2B, GRIN2C, GRIN2D, ACCN3, certain splice forms of GRIN1, KCND2, CXADR and SYNGAP1. Interacts through its second PDZ domain with the PDZ domain of NOS1 or the C-terminus of CAPON. May interact with HTR2A. Interacts through its guanylate kinase-like domain with DLGAP1/GKAP, DLGAP2, DLGAP3, DLGAP4, MAP1A and BEGAIN. Interacts through its third PDZ domain with CRIPT (By similarity). Interacts through its first two PDZ domains with KCNA1, KCNA2, KCNA3, KCNA4 and ERBB4. Interacts through its first PDZ domain with GRIK2, KCNA4 and CRIPT. Interacts through its third PDZ domain with NLGN1, and probably with NLGN2 and NLGN3. Interacts through its guanylate kinase-like domain with KIF13B. Isoform 2 interacts through an L27 domain with HGS/HRS and the first L27 domain of CASK. Interacts with LRFN1, LRFN2 and LRFN4. Interacts with ANO2, ADAM22 and LGI1 (By similarity). Interacts with FRMPD4 (via C-terminus). Interacts (via PDZ1 and PDZ2 domains) with LRRC4; LRRC4B and SEMA4C. Interacts (via guanylate kinase-like domain) with SIPA1L1.

Uniprot	P78352
Gene Name	DLG4
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:1742
Unigene	Hs.463928

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SKU	Supplier No.	Size	Your price	Quantity
BHE13803312	E12411h	96T	$736		Add to Cart

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