Activating transcription factor 4 ; Cyclic AMP-responsive element-binding protein 2 ; CREB-2 ; DNA-binding protein TAXREB67 ; Tax-responsive enhancer element-binding protein 67 ; TaxREB67 ; CREB2 ; TXREB
Categories
Elisa
Function
Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I.
Specificity
Natural and recombinant Human Cyclic AMP-dependent transcription factor ATF-4
Subcellular Location
Cytoplasm Cell membrane Nucleus Cytoplasm cytoskeleton centrosome Colocalizes with GABBR1 in hippocampal neuron dendritic membranes (By similarity). Co-localizes with NEK6 in the centrosome.
Interaction with SATB2 results in enhanced DNA binding and transactivation by these transcription factors (By similarity). Interacts with the C-terminal region of GABBR1 via the leucine zipper of its C-terminal bZIP domain. Interacts with the C-terminal region of GABBR2 (By similarity). Binds DNA as a homo- or heterodimer. Interacts with the N-terminal region of CEP290. Forms a heterodimer with TXLNG in osteoblasts. Interacts with NEK6.