Microtubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interaction with ARHGEF2 to control lamellipodial formation and cell mobility. Does not seem to have protease activity as it has lost the active site residues.
Specificity
Natural and recombinant Human Calpain-6
Subcellular Location
Cytoplasm perinuclear region Cytoplasm cytoskeleton spindle During mitose associated with the mitotic spindle. At telophase colocalized to the midbody spindle.