The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2.
Specificity
Natural and recombinant Human BH3-interacting domain death agonist
Subcellular Location
Isoform 2 Mitochondrion membrane A significant proportion of isoform 2 localizes to mitochondria, it may be cleaved constitutively.