Apoptosis regulator BAK ; Bcl-2-like protein 7 ; Bcl2-L-7 ; BAK ; BCL2L7 ; CDN1
Categories
Elisa
Function
In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti-apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis.
Specificity
Natural and recombinant Human Bcl-2 homologous antagonist/killer
Subcellular Location
Mitochondrion membrane Single-pass membrane protein
Interacts with BCL2A1 (By similarity). Homodimer. Formation of the homodimer is zinc-dependent. Forms heterodimers with BCL2, E1B 19k protein, and BCL2L1 isoform Bcl-X(L). Interacts with myxoma virus protein M11L.