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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Baculoviral IAP repeat-containing protein 5

SKU : BHE13801579

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2045h
Alternative Names	Apoptosis inhibitor 4 ; Apoptosis inhibitor survivin ; API4 ; IAP4
Categories	Elisa
Function	Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May play a role in neoplasia. May counteract a default induction of apoptosis in G2/M phase. Inhibitor of caspase-3 and caspase-7. Isoform 2 and isoform 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform.
Specificity	Natural and recombinant Human Baculoviral IAP repeat-containing protein 5
Subcellular Location	Cytoplasm Nucleus Chromosome Chromosome centromere Cytoplasm cytoskeleton spindle Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalizes with AURKB at mitotic chromosomes.
Detection Range	0.156-10ng/mL
Entryname	BIRC5_HUMAN
Method Type	Sandwich
Platform	PF00653
Protein Name	Baculoviral IAP repeat-containing protein 5
Sensitivity	0.078ng/mL
Sequence	50: MGAPTLPPAW ; QPFLKDHRIS ; TFKNWPFLEG ; CACTPERMAE ; AGFIHCPTEN ; 100: EPDLAQCFFC ; FKELEGWEPD ; DDPIEEHKKH ; SSGCAFLSVK ; KQFEELTLGE ; 142: FLKLDRERAK ; NKIAKETNNK ; KKEFEETAEK ; VRRAIEQLAA ; MD
Sequence Length	142
String	O15392
Sub Unit	Monomer or homodimer. Exist as a homodimer in the apo state and as a monomer in the CPC-bound state. When phosphorylated, interacts with HBXIP; the resulting complex binds pro-caspase-9, as well as active caspase-9, but much less efficiently. Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB and AURKC. Interacts with JTB. Interacts with CDCA8 and INCENP; interaction is direct. Interacts with EVI5. Interacts with GTP-bound RAN in both the S and M phases of the cell cycle. Interacts with USP9X. Interacts with tubulin.

Uniprot	O15392
Gene Name	BIRC5
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:332
Unigene	Hs.514527

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SKU	Supplier No.	Size	Your price	Quantity
BHE13801579	E2045h	96T	$536		Add to Cart

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