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Home / Assay Kits / ELISA Kits

ELISA Kit for Human B-cell linker protein

SKU : BHE13801886

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1600h
Alternative Names	B-cell adapter containing a SH2 domain protein ; B-cell adapter containing a Src homology 2 domain protein ; Cytoplasmic adapter protein ; Src homology 2 domain-containing leukocyte protein of 65 kDa ; SLP-65 ; BASH ; SLP65
Categories	Elisa
Function	Functions as a central linker protein that bridges kinases associated with the B-cell receptor (BCR) with a multitude of signaling pathways, regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition (By similarity). Plays an important role in BCR-induced B-cell apoptosis.
Specificity	Natural and recombinant Human B-cell linker protein
Subcellular Location	Cytoplasm Cell membrane BCR activation results in the translocation to membrane fraction.
Detection Range	78-5000pg/mL
Entryname	BLNK_HUMAN
Method Type	Sandwich
Platform	PF00017
Protein Name	B-cell linker protein
Sensitivity	41.6pg/mL
Sequence	50: MDKLNKITVP ; ASQKLRQLQK ; MVHDIKNNEG ; GIMNKIKKLK ; VKAPPSVPRR ; 100: DYASESPADE ; EEQWSDDFDS ; DYENPDEHSD ; SEMYVMPAEE ; NADDSYEPPP ; 150: VEQETRPVHP ; ALPFARGEYI ; DNRSSQRHSP ; PFSKTLPSKP ; SWPSEKARLT ; 200: STLPALTALQ ; KPQVPPKPKG ; LLEDEADYVV ; PVEDNDENYI ; HPTESSSPPP ; 250: EKAPMVNRST ; KPNSSTPASP ; PGTASGRNSG ; AWETKSPPPA ; APSPLPRAGK ; 300: KPTTPLKTTP ; VASQQNASSV ; CEEKPIPAER ; HRGSSHRQEA ; VQSPVFPPAQ ; 350: KQIHQKPIPL ; PRFTEGGNPT ; VDGPLPSFSS ; NSTISEQEAG ; VLCKPWYAGA ; 400: CDRKSAEEAL ; HRSNKDGSFL ; IRKSSGHDSK ; QPYTLVVFFN ; KRVYNIPVRF ; 450: IEATKQYALG ; RKKNGEEYFG ; SVAEIIRNHQ ; HSPLVLIDSQ ; NNTKDSTRLK ; 456: YAVKVS
Sequence Length	456
String	Q8WV28
Sub Unit	Associates with PLCG1, VAV1 and NCK1 in a B-cell antigen receptor-dependent fashion. Interacts with VAV3, PLCG2 and GRB2. Interacts through its SH2 domain with CD79A.

Uniprot	Q8WV28
Gene Name	BLNK
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:29760
Unigene	Hs.665244

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SKU	Supplier No.	Size	Your price	Quantity
BHE13801886	E1600h	96T	$736		Add to Cart

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