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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Atypical chemokine receptor 2

SKU : BHE13800717

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E14064h
Alternative Names	C-C chemokine receptor D6 ; Chemokine receptor CCR-10 ; Chemokine receptor CCR-9 ; Chemokine-binding protein 2 ; Chemokine-binding protein D6 ; CCBP2 ; CCR10 ; CMKBR9 ; D6
Categories	Elisa
Function	Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines including CCL2, CCL3, CCL3L1, CCL4, CCL5, CCL7, CCL8, CCL11, CCL13, CCL17, CCL22, CCL23, CCL24, SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/MCP-3. Upon active ligand stimulation, activates a beta-arrestin 1 (ARRB1)-dependent, G protein-independent signaling pathway that results in the phosphorylation of the actin-binding protein cofilin (CFL1) through a RAC1-PAK1-LIMK1 signaling pathway. Activation of this pathway results in up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. By scavenging chemokines in tissues, on the surfaces of lymphatic vessels, and in placenta, plays an essential role in the resolution (termination) of the inflammatory response and in the regulation of adaptive immune responses. Plays a major role in the immune silencing of macrophages during the resolution of inflammation. Acts as a regulator of inflammatory leukocyte interactions with lymphatic endothelial cells (LECs) and is required for immature/mature dendritic cells discrimination by LECs.
Specificity	Natural and recombinant Human Atypical chemokine receptor 2
Subcellular Location	Early endosome Recycling endosome Cell membrane Multi-pass membrane protein Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via clathrin-coated pits. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane.
Detection Range	31.2-2000pg/mL
Entryname	ACKR2_HUMAN
Method Type	Sandwich
Platform	PF00001
Protein Name	Atypical chemokine receptor 2
Sensitivity	9.5pg/mL
Sequence	50: MAATASPQPL ; ATEDADSENS ; SFYYYDYLDE ; VAFMLCRKDA ; VVSFGKVFLP ; 100: VFYSLIFVLG ; LSGNLLLLMV ; LLRYVPRRRM ; VEIYLLNLAI ; SNLLFLVTLP ; 150: FWGISVAWHW ; VFGSFLCKMV ; STLYTINFYS ; GIFFISCMSL ; DKYLEIVHAQ ; 200: PYHRLRTRAK ; SLLLATIVWA ; VSLAVSIPDM ; VFVQTHENPK ; GVWNCHADFG ; 250: GHGTIWKLFL ; RFQQNLLGFL ; LPLLAMIFFY ; SRIGCVLVRL ; RPAGQGRALK ; 300: IAAALVVAFF ; VLWFPYNLTL ; FLHTLLDLQV ; FGNCEVSQHL ; DYALQVTESI ; 350: AFLHCCFSPI ; LYAFSSHRFR ; QYLKAFLAAV ; LGWHLAPGTA ; QASLSSCSES ; 384: SILTAQEEMT ; GMNDLGERQS ; ENYPNKEDVG ; NKSA
Sequence Length	384

Uniprot	O00590
Gene Name	ACKR2
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:1238
Unigene	Hs.146346

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SKU	Supplier No.	Size	Your price	Quantity
BHE13800717	E14064h	96T	$736		Add to Cart

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