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ELISA Kit for Human AT-rich interactive domain-containing protein 1A

SKU : BHE13801377

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E14644h
Alternative Names	B120 ; BRG1-associated factor 250 ; BAF250 ; BRG1-associated factor 250a ; BAF250A ; Osa homolog 1 ; hOSA1 ; SWI-like protein ; SWI/SNF complex protein p270 ; SWI/SNF-related ; matrix-associated ; actin-dependent regulator of chromatin subfamily F member 1 ; hELD ; BAF250 ; BAF250A ; C1orf4 ; OSA1 ; SMARCF1
Categories	Elisa
Function	Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Binds DNA non-specifically. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.
Specificity	Natural and recombinant Human AT-rich interactive domain-containing protein 1A
Subcellular Location	Nucleus
Entryname	ARI1A_HUMAN
Platform	PF01388
Protein Name	AT-rich interactive domain-containing protein 1A
Sequence	50: MAAQVAPAAA ; SSLGNPPPPP ; PSELKKAEQQ ; QREEAGGEAA ; AAAAAERGEM ; 100: KAAAGQESEG ; PAVGPPQPLG ; KELQDGAESN ; GGGGGGGAGS ; GGGPGAEPDL ; 150: KNSNGNAGPR ; PALNNNLTEP ; PGGGGGGSSD ; GVGAPPHSAA ; AALPPPAYGF ; 200: GQPYGRSPSA ; VAAAAAAVFH ; QQHGGQQSPG ; LAALQSGGGG ; GLEPYAGPQQ ; 250: NSHDHGFPNH ; QYNSYYPNRS ; AYPPPAPAYA ; LSSPRGGTPG ; SGAAAAAGSK ; 300: PPPSSSASAS ; SSSSSFAQQR ; FGAMGGGGPS ; AAGGGTPQPT ; ATPTLNQLLT ; 350: SPSSARGYQG ; YPGGDYSGGP ; QDGGAGKGPA ; DMASQCWGAA ; AAAAAAAAAS ; 400: GGAQQRSHHA ; PMSPGSSGGG ; GQPLARTPQP ; SSPMDQMGKM ; RPQPYGGTNP ; 450: YSQQQGPPSG ; PQQGHGYPGQ ; PYGSQTPQRY ; PMTMQGRAQS ; AMGGLSYTQQ ; 500: IPPYGQQGPS ; GYGQQGQTPY ; YNQQSPHPQQ ; QQPPYSQQPP ; SQTPHAQPSY ; 550: QQQPQSQPPQ ; LQSSQPPYSQ ; QPSQPPHQQS ; PAPYPSQQST ; TQQHPQSQPP ; 600: YSQPQAQSPY ; QQQQPQQPAP ; STLSQQAAYP ; QPQSQQSQQT ; AYSQQRFPPP ; 650: QELSQDSFGS ; QASSAPSMTS ; SKGGQEDMNL ; SLQSRPSSLP ; DLSGSIDDLP ; 700: MGTEGALSPG ; VSTSGISSSQ ; GEQSNPAQSP ; FSPHTSPHLP ; GIRGPSPSPV ; 750: GSPASVAQSR ; SGPLSPAAVP ; GNQMPPRPPS ; GQSDSIMHPS ; MNQSSIAQDR ; 800: GYMQRNPQMP ; QYSSPQPGSA ; LSPRQPSGGQ ; IHTGMGSYQQ ; NSMGSYGPQG ; 850: GQYGPQGGYP ; RQPNYNALPN ; ANYPSAGMAG ; GINPMGAGGQ ; MHGQPGIPPY ; 900: GTLPPGRMSH ; ASMGNRPYGP ; NMANMPPQVG ; SGMCPPPGGM ; NRKTQETAVA ; 950: MHVAANSIQN ; RPPGYPNMNQ ; GGMMGTGPPY ; GQGINSMAGM ; INPQGPPYSM ; 1000: GGTMANNSAG ; MAASPEMMGL ; GDVKLTPATK ; MNNKADGTPK ; TESKSKKSSS ; 1050: STTTNEKITK ; LYELGGEPER ; KMWVDRYLAF ; TEEKAMGMTN ; LPAVGRKPLD ; 1100: LYRLYVSVKE ; IGGLTQVNKN ; KKWRELATNL ; NVGTSSSAAS ; SLKKQYIQCL ; 1150: YAFECKIERG ; EDPPPDIFAA ; ADSKKSQPKI ; QPPSPAGSGS ; MQGPQTPQST ; 1200: SSSMAEGGDL ; KPPTPASTPH ; SQIPPLPGMS ; RSNSVGIQDA ; FNDGSDSTFQ ; 1250: KRNSMTPNPG ; YQPSMNTSDM ; MGRMSYEPNK ; DPYGSMRKAP ; GSDPFMSSGQ ; 1300: GPNGGMGDPY ; SRAAGPGLGN ; VAMGPRQHYP ; YGGPYDRVRT ; EPGIGPEGNM ; 1350: STGAPQPNLM ; PSNPDSGMYS ; PSRYPPQQQQ ; QQQQRHDSYG ; NQFSTQGTPS ; 1400: GSPFPSQQTT ; MYQQQQQNYK ; RPMDGTYGPP ; AKRHEGEMYS ; VPYSTGQGQP ; 1450: QQQQLPPAQP ; QPASQQQAAQ ; PSPQQDVYNQ ; YGNAYPATAT ; AATERRPAGG ; 1500: PQNQFPFQFG ; RDRVSAPPGT ; NAQQNMPPQM ; MGGPIQASAE ; VAQQGTMWQG ; 1550: RNDMTYNYAN ; RQSTGSAPQG ; PAYHGVNRTD ; EMLHTDQRAN ; HEGSWPSHGT ; 1600: RQPPYGPSAP ; VPPMTRPPPS ; NYQPPPSMQN ; HIPQVSSPAP ; LPRPMENRTS ; 1650: PSKSPFLHSG ; MKMQKAGPPV ; PASHIAPAPV ; QPPMIRRDIT ; FPPGSVEATQ ; 1700: PVLKQRRRLT ; MKDIGTPEAW ; RVMMSLKSGL ; LAESTWALDT ; INILLYDDNS ; 1750: IMTFNLSQLP ; GLLELLVEYF ; RRCLIEIFGI ; LKEYEVGDPG ; QRTLLDPGRF ; 1800: SKVSSPAPME ; GGEEEEELLG ; PKLEEEEEEE ; VVENDEEIAF ; SGKDKPASEN ; 1850: SEEKLISKFD ; KLPVKIVQKN ; DPFVVDCSDK ; LGRVQEFDSG ; LLHWRIGGGD ; 1900: TTEHIQTHFE ; SKTELLPSRP ; HAPCPPAPRK ; HVTTAEGTPG ; TTDQEGPPPD ; 1950: GPPEKRITAT ; MDDMLSTRSS ; TLTEDGAKSS ; EAIKESSKFP ; FGISPAQSHR ; 2000: NIKILEDEPH ; SKDETPLCTL ; LDWQDSLAKR ; CVCVSNTIRS ; LSFVPGNDFE ; 2050: MSKHPGLLLI ; LGKLILLHHK ; HPERKQAPLT ; YEKEEEQDQG ; VSCNKVEWWW ; 2100: DCLEMLRENT ; LVTLANISGQ ; LDLSPYPESI ; CLPVLDGLLH ; WAVCPSAEAQ ; 2150: DPFSTLGPNA ; VLSPQRLVLE ; TLSKLSIQDN ; NVDLILATPP ; FSRLEKLYST ; 2200: MVRFLSDRKN ; PVCREMAVVL ; LANLAQGDSL ; AARAIAVQKG ; SIGNLLGFLE ; 2250: DSLAATQFQQ ; SQASLLHMQN ; PPFEPTSVDM ; MRRAARALLA ; LAKVDENHSE ; 2285: FTLYESRLLD ; ISVSPLMNSL ; VSQVICDVLF ; LIGQS
Sequence Length	2285
String	O14497
Sub Unit	Component of SWI/SNF chromatin remodeling complexes, in some of which it can be mutually exclusive with ARID1B/BAF250B. Component of the BAF (SWI/SNF-A) complex, which includes at least actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3. Component of the SWI/SNF-B (PBAF) complex, at least composed of SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCD2/BAF60B, perhaps SMARCD3/BAF60C, SMARCC1/BAF155, SMARCC2/BAF170, PB1/BAF180, ARID2/BAF200, ARID1A/BAF250A or ARID1B/BAF250B and actin. Component of the SWI/SNF Brm complex, at least composed of SMARCA2/BRM/BAF190B, SMARCB1/BAF47, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, BAF60 (one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C), SMARCC1/BAF155, SMARCC2/BAF170, ARID1A/BAF250A, SIN3A, HDAC1, HDAC2, and RBAP4. Component of the SWI/SNF complex Brg1(I), at least composed of SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, BAF60 (one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C), SMARCC1/BAF155, SMARCC2/BAF170, ARID1A/BAF250A, SIN3A, and probably HDAC2 and RBAP4. Component of the SWI/SNF Brg1(II), at least composed of SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, ARID1A/BAF250A and probably HDAC2 and RBAP4. Component of a SWI/SNF-like EPAFa complex, at least composed of SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, ACTL6A/BAF53A, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCC1/BAF155, SMARCC2/BAF170, BAF250A and MLLT1/ENL. Component of a SWI/SNF-like complex containing ARID1A/BAF250A and ARID1B/BAF250B. Interacts through its C-terminus with SMARCA2/BRM/BAF190B and SMARCA4/BRG1/BAF190A. Component of the WINAC complex, at least composed of SMARCA2, SMARCA4, SMARCB1, SMARCC1, SMARCC2, SMARCD1, SMARCE1, ACTL6A, BAZ1B/WSTF, ARID1A, SUPT16H, CHAF1A and TOP2B. Interacts with SMARCC1/BAF155. Component of neural progenitors-specific chromatin remodeling complex (npBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A and actin. Component of neuron-specific chromatin remodeling complex (nBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B and actin.

Uniprot	O14497
Gene Name	ARID1A
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:8289
Unigene	Hs.468972

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