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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Asporin

SKU : BHE13801762

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1043h
Alternative Names	Periodontal ligament-associated protein 1 ; PLAP-1 ; PLAP1 ; SLRR1C ; UNQ215/PRO241
Categories	Elisa
Function	Negatively regulates periodontal ligament (PDL) differentiation and mineralization to ensure that the PDL is not ossified and to maintain homeostasis of the tooth-supporting system. Inhibits BMP2-induced cytodifferentiation of PDL cells by preventing its binding to the BMP receptor-IB (BMPR-IB), resulting in inhibition of BMP-dependent activation of SMAD proteins (By similarity). Critical regulator of TGF-beta in articular cartilage and plays an essential role in cartilage homeostasis and osteoarthritis (OA) pathogenesis. Negatively regulates chondrogenesis in the articular cartilage by blocking the TGF-beta/receptor interaction on the cell surface and inhibiting the canonical TGF-beta/Smad signal. Binds calcium and plays a role in osteoblast-driven collagen biomineralization activity.
Specificity	Natural and recombinant Human Asporin
Subcellular Location	Secreted extracellular space extracellular matrix
Detection Range	0.156-10ng/mL
Entryname	ASPN_HUMAN
Method Type	Sandwich
Platform	PF00560
Protein Name	Asporin
Sensitivity	0.078ng/mL
Sequence	50: MKEYVLLLFL ; ALCSAKPFFS ; PSHIALKNMM ; LKDMEDTDDD ; DDDDDDDDDD ; 100: DEDNSLFPTR ; EPRSHFFPFD ; LFPMCPFGCQ ; CYSRVVHCSD ; LGLTSVPTNI ; 150: PFDTRMLDLQ ; NNKIKEIKEN ; DFKGLTSLYG ; LILNNNKLTK ; IHPKAFLTTK ; 200: KLRRLYLSHN ; QLSEIPLNLP ; KSLAELRIHE ; NKVKKIQKDT ; FKGMNALHVL ; 250: EMSANPLDNN ; GIEPGAFEGV ; TVFHIRIAEA ; KLTSVPKGLP ; PTLLELHLDY ; 300: NKISTVELED ; FKRYKELQRL ; GLGNNKITDI ; ENGSLANIPR ; VREIHLENNK ; 350: LKKIPSGLPE ; LKYLQIIFLH ; SNSIARVGVN ; DFCPTVPKMK ; KSLYSAISLF ; 380: NNPVKYWEMQ ; PATFRCVLSR ; MSVQLGNFGM ;
Sequence Length	380
String	Q9BXN1
Sub Unit	Interacts with TGFB1, TGFB2 and TGFB3. DCN, BGN, and FMOD inhibit binding to TGFB1. Interacts with BMP2. Interacts in vitro with type II collagen (By similarity). Interacts with type I collagen. DCN can inhibit collagen binding.

Uniprot	Q9BXN1
Gene Name	ASPN
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:54829
Unigene	Hs.435655

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SKU	Supplier No.	Size	Your price	Quantity
BHE13801762	E1043h	96T	$736		Add to Cart

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