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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Apoptosis regulator Bcl-2

SKU : BHE13801783

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0778h
Categories	Elisa
Function	Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).
Specificity	Natural and recombinant Human Apoptosis regulator Bcl-2
Subcellular Location	Mitochondrion outer membrane Single-pass membrane protein Nucleus membrane Single-pass membrane protein Endoplasmic reticulum membrane Single-pass membrane protein
Detection Range	78-5000pg/mL
Entryname	BCL2_HUMAN
Method Type	Sandwich
Platform	PF00452
Protein Name	Apoptosis regulator Bcl-2
Sensitivity	30pg/mL
Sequence	50: MAHAGRTGYD ; NREIVMKYIH ; YKLSQRGYEW ; DAGDVGAAPP ; GAAPAPGIFS ; 100: SQPGHTPHPA ; ASRDPVARTS ; PLQTPAAPGA ; AAGPALSPVP ; PVVHLTLRQA ; 150: GDDFSRRYRR ; DFAEMSSQLH ; LTPFTARGRF ; ATVVEELFRD ; GVNWGRIVAF ; 200: FEFGGVMCVE ; SVNREMSPLV ; DNIALWMTEY ; LNRHLHTWIQ ; DNGGWDAFVE ; 239: LYGPSMRPLF ; DFSWLSLKTL ; LSLALVGACI ; TLGAYLGHK
Sequence Length	239
String	P10415
Sub Unit	Forms homodimers, and heterodimers with BAX, BAD, BAK and Bcl-X(L). Heterodimerization with BAX requires intact BH1 and BH2 motifs, and is necessary for anti-apoptotic activity (By similarity). Also interacts with APAF1, BBC3, BCL2L1, BNIPL, EI24, MRPL41, RAF-1 and TP53BP2. Binding to FKBP8 seems to target BCL2 to the mitochondria and probably interferes with the binding of BCL2 to its targets. Interacts with BAG1 in an ATP-dependent manner.

Uniprot	P10415
Gene Name	BCL2
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:596
Unigene	Hs.150749

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SKU	Supplier No.	Size	Your price	Quantity
BHE13801783	E0778h	96T	$736		Add to Cart

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