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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Apoptosis regulator BAX

SKU : BHE13801478

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1343h
Alternative Names	Bcl-2-like protein 4 ; Bcl2-L-4 ; BCL2L4
Categories	Elisa
Function	Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.
Specificity	Natural and recombinant Human Apoptosis regulator BAX
Subcellular Location	Isoform Delta Cytoplasm
Detection Range	0.312-20ng/mL
Entryname	BAX_HUMAN
Method Type	Sandwich
Platform	PF00452
Protein Name	Apoptosis regulator BAX
Sensitivity	0.11ng/mL
Sequence	50: MDGSGEQPRG ; GGPTSSEQIM ; KTGALLLQGF ; IQDRAGRMGG ; EAPELALDPV ; 100: PQDASTKKLS ; ECLKRIGDEL ; DSNMELQRMI ; AAVDTDSPRE ; VFFRVAADMF ; 150: SDGNFNWGRV ; VALFYFASKL ; VLKALCTKVP ; ELIRTIMGWT ; LDFLRERLLG ; 192: WIQDQGGWDG ; LLSYFGTPTW ; QTVTIFVAGV ; LTASLTIWKK ; MG
Sequence Length	192
String	Q07812
Sub Unit	Homodimer. Forms higher oligomers under stress conditions. Interacts with BCL2L11. Interaction with BCL2L11 promotes BAX oligomerization and association with mitochondrial membranes, with subsequent release of cytochrome c. Forms heterodimers with BCL2, E1B 19K protein, BCL2L1 isoform Bcl-X(L), BCL2L2, MCL1 and A1. Interacts with SH3GLB1 and HN. Interacts with SFN and YWHAZ; the interaction occurs in the cytoplasm. Under stress conditions, JNK-mediated phosphorylation of SFN and YWHAZ, releases BAX to mitochondria. Isoform Sigma interacts with BCL2A1 and BCL2L1 isoform Bcl-X(L). Interacts with RNF144B, which regulates the ubiquitin-dependent stability of BAX. Interacts with CLU under stress conditions that cause a conformation change leading to BAX oligomerization and association with mitochondria. Does not interact with CLU in unstressed cells.

Uniprot	Q07812
Gene Name	BAX
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:581
Unigene	Hs.624291

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SKU	Supplier No.	Size	Your price	Quantity
BHE13801478	E1343h	96T	$736		Add to Cart

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