JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
[email protected]

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / Assay Kits / ELISA Kits

ELISA Kit for Human Apoptosis-inducing factor 1, mitochondrial

SKU : BHE13801041

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Request More Infos

EIAAB SCIENCE INC, WUHAN

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Mfr.No.	E1064h
Alternative Names	Programmed cell death protein 8 ; AIF ; PDCD8
Categories	Elisa
Function	Probable oxidoreductase that has a dual role in controlling cellular life and death; during apoptosis, it is translocated from the mitochondria to the nucleus to function as a proapoptotic factor in a caspase-independent pathway, while in normal mitochondria, it functions as an antiapoptotic factor via its oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e., caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner.
Specificity	Natural and recombinant Human Apoptosis-inducing factor 1, mitochondrial
Subcellular Location	Mitochondrion intermembrane space Mitochondrion inner membrane Cytoplasm Nucleus Cytoplasm perinuclear region Proteolytic cleavage during or just after translocation into the mitochondrial intermembrane space (IMS) results in the formation of an inner-membrane-anchored mature form (AIFmit). During apoptosis, further proteolytic processing leads to a mature form, which is confined to the mitochondrial IMS in a soluble form (AIFsol). AIFsol is released to the cytoplasm in response to specific death signals, and translocated to the nucleus, where it induces nuclear apoptosis. Colocalizes with EIF3G in the nucleus and perinuclear region.
Detection Range	0.156-10ng/mL
Entryname	AIFM1_HUMAN
Method Type	Sandwich
Platform	PF00070
Protein Name	Apoptosis-inducing factor 1, mitochondrial
Sensitivity	0.056ng/mL
Sequence	50: MFRCGGLAAG ; ALKQKLVPLV ; RTVCVRSPRQ ; RNRLPGNLFQ ; RWHVPLELQM ; 100: TRQMASSGAS ; GGKIDNSVLV ; LIVGLSTVGA ; GAYAYKTMKE ; DEKRYNERIS ; 150: GLGLTPEQKQ ; KKAALSASEG ; EEVPQDKAPS ; HVPFLLIGGG ; TAAFAAARSI ; 200: RARDPGARVL ; IVSEDPELPY ; MRPPLSKELW ; FSDDPNVTKT ; LRFKQWNGKE ; 250: RSIYFQPPSF ; YVSAQDLPHI ; ENGGVAVLTG ; KKVVQLDVRD ; NMVKLNDGSQ ; 300: ITYEKCLIAT ; GGTPRSLSAI ; DRAGAEVKSR ; TTLFRKIGDF ; RSLEKISREV ; 350: KSITIIGGGF ; LGSELACALG ; RKARALGTEV ; IQLFPEKGNM ; GKILPEYLSN ; 400: WTMEKVRREG ; VKVMPNAIVQ ; SVGVSSGKLL ; IKLKDGRKVE ; TDHIVAAVGL ; 450: EPNVELAKTG ; GLEIDSDFGG ; FRVNAELQAR ; SNIWVAGDAA ; CFYDIKLGRR ; 500: RVEHHDHAVV ; SGRLAGENMT ; GAAKPYWHQS ; MFWSDLGPDV ; GYEAIGLVDS ; 550: SLPTVGVFAK ; ATAQDNPKSA ; TEQSGTGIRS ; ESETESEASE ; ITIPPSTPAV ; 600: PQAPVQGEDY ; GKGVIFYLRD ; KVVVGIVLWN ; IFNRMPIARK ; IIKDGEQHED ; 613: LNEVAKLFNI ; HED
Sequence Length	613
String	O95831
Sub Unit	Interacts with XIAP. Interacts (via N-terminus) with EIF3G (via C-terminus).

Uniprot	O95831
Gene Name	AIFM1
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:51060
Unigene	Hs.424932

Have you used this product?

Rate it now..!!

Login to Review

SKU	Supplier No.	Size	Your price	Quantity
BHE13801041	E1064h	96T	$536		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2024 Biohippo. All rights reserved.