AP-mu chain family member mu1A ; Adaptor protein complex AP-1 subunit mu-1 ; Adaptor-related protein complex 1 subunit mu-1 ; Clathrin assembly protein complex 1 mu-1 medium chain 1 ; Clathrin coat assembly protein AP47 ; Clathrin coat-associated protein AP47 ; Golgi adaptor HA1/AP1 adaptin mu-1 subunit ; Mu-adaptin 1 ; Mu1A-adaptin ; CLTNM
Categories
Elisa
Function
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
Specificity
Natural and recombinant Human AP-1 complex subunit mu-1
Subcellular Location
Golgi apparatus Cytoplasmic vesicle clathrin-coated vesicle membrane Peripheral membrane protein Cytoplasmic side Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
Adaptor protein complex 1 (AP-1) is an heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3). Interacts with MARCH11 (By similarity). Interacts with HIV-1 Nef. Associates with the AP1(MU)-Nef-MHC-I complex; this complex is required for MHC-I internalization.