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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Antigen peptide transporter 2

SKU : BHE13811209

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E10018h
Alternative Names	ATP-binding cassette sub-family B member 3 ; Peptide supply factor 2 ; Peptide transporter PSF2 ; PSF-2 ; Peptide transporter TAP2 ; Peptide transporter involved in antigen processing 2 ; Really interesting new gene 11 protein ; ABCB3 ; PSF2 ; RING11 ; Y1
Categories	Elisa
Function	Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association.
Specificity	Natural and recombinant Human Antigen peptide transporter 2
Subcellular Location	Endoplasmic reticulum membrane Multi-pass membrane protein The transmembrane segments seem to form a pore in the membrane.
Detection Range	0.625-40ng/mL
Entryname	TAP2_HUMAN
Method Type	Competitive
Platform	PF00664
Protein Name	Antigen peptide transporter 2
Sensitivity	0.307ng/mL
Sequence	50: MRLPDLRPWT ; SLLLVDAALL ; WLLQGPLGTL ; LPQGLPGLWL ; EGTLRLGGLW ; 100: GLLKLRGLLG ; FVGTLLLPLC ; LATPLTVSLR ; ALVAGASRAP ; PARVASAPWS ; 150: WLLVGYGAAG ; LSWSLWAVLS ; PPGAQEKEQD ; QVNNKVLMWR ; LLKLSRPDLP ; 200: LLVAAFFFLV ; LAVLGETLIP ; HYSGRVIDIL ; GGDFDPHAFA ; SAIFFMCLFS ; 250: FGSSLSAGCR ; GGCFTYTMSR ; INLRIREQLF ; SSLLRQDLGF ; FQETKTGELN ; 300: SRLSSDTTLM ; SNWLPLNANV ; LLRSLVKVVG ; LYGFMLSISP ; RLTLLSLLHM ; 350: PFTIAAEKVY ; NTRHQEVLRE ; IQDAVARAGQ ; VVREAVGGLQ ; TVRSFGAEEH ; 400: EVCRYKEALE ; QCRQLYWRRD ; LERALYLLVR ; RVLHLGVQML ; MLSCGLQQMQ ; 450: DGELTQGSLL ; SFMIYQESVG ; SYVQTLVYIY ; GDMLSNVGAA ; EKVFSYMDRQ ; 500: PNLPSPGTLA ; PTTLQGVVKF ; QDVSFAYPNR ; PDRPVLKGLT ; FTLRPGEVTA ; 550: LVGPNGSGKS ; TVAALLQNLY ; QPTGGQVLLD ; EKPISQYEHC ; YLHSQVVSVG ; 600: QEPVLFSGSV ; RNNIAYGLQS ; CEDDKVMAAA ; QAAHADDFIQ ; EMEHGIYTDV ; 650: GEKGSQLAAG ; QKQRLAIARA ; LVRDPRVLIL ; DEATSALDVQ ; CEQALQDWNS ; 686: RGDRTVLVIA ; HRLQTVQRAH ; QILVLQEGKL ; QKLAQL
Sequence Length	686
Sub Unit	Heterodimer of TAP1 and TAP2. Interacts with Epstein-Barr virus BLNF2a.

Uniprot	Q03519
Gene Name	TAP2
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:6891
Unigene	Hs.502

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SKU	Supplier No.	Size	Your price	Quantity
BHE13811209	E10018h	96T	$736		Add to Cart

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