Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu- ; -Ala-393' site.
Specificity
Natural and recombinant Human A disintegrin and metalloproteinase with thrombospondin motifs 4