This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. This receptor is involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production.
Specificity
Natural and recombinant Human 5-hydroxytryptamine receptor 2A
Subcellular Location
Cell membrane Multi-pass membrane protein Localizes to the post-synaptic thickening of axo-dendritic synapses.