JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
[email protected]

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / Assay Kits / ELISA Kits

ELISA Kit for Human 4F2 cell-surface antigen heavy chain

SKU : BHE13800210

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Request More Infos

EIAAB SCIENCE INC, WUHAN

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Mfr.No.	E2005h
Alternative Names	4F2 heavy chain antigen ; Lymphocyte activation antigen 4F2 large subunit ; Solute carrier family 3 member 2 ; CD98 ; MDU1
Categories	Elisa
Function	Required for the function of light chain amino-acid transporters. Involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. Involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7 acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Required for normal and neoplastic cell growth. When associated with SLC7A5/LAT1, is also involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. When associated with SLC7A5 or SLC7A8, involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Together with ICAM1, regulates the transport activity LAT2 in polarized intestinal cells, by generating and delivering intracellular signals. When associated with SLC7A5, plays an important role in transporting L-leucine from the circulating blood to the retina across the inner blood-retinal barrier.
Specificity	Natural and recombinant Human 4F2 cell-surface antigen heavy chain
Subcellular Location	Apical cell membrane Single-pass type II membrane protein Melanosome Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Localized to the plasma membrane when associated with SLC7A5 or SLC7A8. Localized to the placental apical membrane. Located selectively at cell-cell adhesion sites (By similarity). Colocalized with SLC7A8/LAT2 at the basolateral membrane of kidney proximal tubules and small intestine epithelia. Expressed in both luminal and abluminal membranes of brain capillary endothelial cells.
Detection Range	0.156-10ng/mL
Entryname	4F2_HUMAN
Method Type	Sandwich
Platform	PF00128
Protein Name	4F2 cell-surface antigen heavy chain
Sensitivity	0.078ng/mL
Sequence	50: MELQPPEASI ; AVVSIPRQLP ; GSHSEAGVQG ; LSAGDDSELG ; SHCVAQTGLE ; 100: LLASGDPLPS ; ASQNAEMIET ; GSDCVTQAGL ; QLLASSDPPA ; LASKNAEVTG ; 150: TMSQDTEVDM ; KEVELNELEP ; EKQPMNAASG ; AAMSLAGAEK ; NGLVKIKVAE ; 200: DEAEAAAAAK ; FTGLSKEELL ; KVAGSPGWVR ; TRWALLLLFW ; LGWLGMLAGA ; 250: VVIIVRAPRC ; RELPAQKWWH ; TGALYRIGDL ; QAFQGHGAGN ; LAGLKGRLDY ; 300: LSSLKVKGLV ; LGPIHKNQKD ; DVAQTDLLQI ; DPNFGSKEDF ; DSLLQSAKKK ; 350: SIRVILDLTP ; NYRGENSWFS ; TQVDTVATKV ; KDALEFWLQA ; GVDGFQVRDI ; 400: ENLKDASSFL ; AEWQNITKGF ; SEDRLLIAGT ; NSSDLQQILS ; LLESNKDLLL ; 450: TSSYLSDSGS ; TGEHTKSLVT ; QYLNATGNRW ; CSWSLSQARL ; LTSFLPAQLL ; 500: RLYQLMLFTL ; PGTPVFSYGD ; EIGLDAAALP ; GQPMEAPVML ; WDESSFPDIP ; 550: GAVSANMTVK ; GQSEDPGSLL ; SLFRRLSDQR ; SKERSLLHGD ; FHAFSAGPGL ; 600: FSYIRHWDQN ; ERFLVVLNFG ; DVGLSAGLQA ; SDLPASASLP ; AKADLLLSTQ ; 630: PGREEGSPLE ; LERLKLEPHE ; GLLLRFPYAA ;
Sequence Length	630
String	P08195
Sub Unit	Disulfide-linked heterodimer of a glycosylated heavy chain and a non-glycosylated light chain (SLC7A5, SLC7A6, SLCA7A7, SLC7A8, SLC7A10 or SLCA7A11). Colocalizes with cadherins (By similarity). Interacts with FAM57A/CT120 and ICAM1. Constitutively and specifically associates with beta-1 integrins (alpha-2/beta-1, alpha-3/beta-1, alpha-5/beta-1 and alpha-6/beta-1), but minimally with alpha-4/beta-1.

Uniprot	P08195
Gene Name	SLC3A2
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:6520
Unigene	Hs.502769

Have you used this product?

Rate it now..!!

Login to Review

SKU	Supplier No.	Size	Your price	Quantity
BHE13800210	E2005h	96T	$736		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2024 Biohippo. All rights reserved.