Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
Specificity
Natural and recombinant Human 3-oxo-5-alpha-steroid 4-dehydrogenase 1
Subcellular Location
Microsome membrane Multi-pass membrane protein Endoplasmic reticulum membrane Multi-pass membrane protein