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Home / Assay Kits / ELISA Kits

ELISA Kit for Human 14-3-3 protein zeta/delta

SKU : BHE13800101

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E14294h
Alternative Names	Protein kinase C inhibitor protein 1 ; KCIP-1
Categories	Elisa
Function	Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
Specificity	Natural and recombinant Human 14-3-3 protein zeta/delta
Subcellular Location	Cytoplasm Melanosome Located to stage I to stage IV melanosomes.
Detection Range	15.6-1000pg/mL
Entryname	1433Z_HUMAN
Method Type	Sandwich
Platform	PF00244
Protein Name	14-3-3 protein zeta/delta
Sensitivity	7.96pg/mL
Sequence	50: MDKNELVQKA ; KLAEQAERYD ; DMAACMKSVT ; EQGAELSNEE ; RNLLSVAYKN ; 100: VVGARRSSWR ; VVSSIEQKTE ; GAEKKQQMAR ; EYREKIETEL ; RDICNDVLSL ; 150: LEKFLIPNAS ; QAESKVFYLK ; MKGDYYRYLA ; EVAAGDDKKG ; IVDQSQQAYQ ; 200: EAFEISKKEM ; QPTHPIRLGL ; ALNFSVFYYE ; ILNSPEKACS ; LAKTAFDEAI ; 245: AELDTLSEES ; YKDSTLIMQL ; LRDNLTLWTS ; DTQGDEAEAG ; EGGEN
Sequence Length	245
String	P63104
Sub Unit	Homodimer. Heterodimerizes with YWHAE. Homo- and hetero-dimerization is inhibited by phosphorylation on Ser-58. Interacts with FOXO4, NOXA1, SSH1 and ARHGEF2. Interacts with CDK16 and BSPRY (By similarity). Interacts with WEE1 (C-terminal). Interacts with SAMSN1 (By similarity). Interacts with MLF1 (phosphorylated form); the interaction retains it in the cytoplasm (By similarity). Interacts with Thr-phosphorylated ITGB2 (By similarity). Interacts with Pseudomonas aeruginosa exoS (unphosphorylated form). Interacts with BAX; the interaction occurs in the cytoplasm. Under stress conditions, MAPK8-mediated phosphorylation releases BAX to mitochondria. Interacts with phosphorylated RAF1; the interaction is inhibited when YWHAZ is phosphorylated on Thr-232. Interacts with TP53; the interaction enhances p53 transcriptional acivity. The Ser-58 phosphorylated form inhibits this interaction and p53 transcriptional activity. Interacts with ABL1 (phosphorylated form); the interaction retains ABL1 in the cytoplasm. Interacts with AANAT ('Thr-31' phosphorylated form); the interaction modulates AANAT enzymatic activity through preventing dephosphorylation and/or proteolysis and stabilizing substrate binding. Subsequently, a second molecule of AANAT ('Ser-205' phosphorylated form), can bind the other YWHAZ monomer with similar effect. Interacts with AKT1; the interaction phosphorylates YWHAZ and modulates dimerization. Interacts with GAB2. Interacts with BCL2L11.

Uniprot	P63104
Gene Name	YWHAZ
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:7534
Unigene	Hs.492407

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SKU	Supplier No.	Size	Your price	Quantity
BHE13800101	E14294h	96T	$736		Add to Cart

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