ELISA Kit for Dog Von Hippel-Lindau disease tumor suppressor

Mfr.No.	E1894d
Alternative Names	pVHL
Categories	Elisa
Function	Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases.
Specificity	Natural and recombinant Dog Von Hippel-Lindau disease tumor suppressor
Subcellular Location	Cytoplasm Membrane Peripheral membrane protein Nucleus
Entryname	VHL_CANFA
Platform	PF01847
Protein Name	Von Hippel-Lindau disease tumor suppressor
Sequence	50: MPRKAGSVEE ; AEAGAEEVGA ; EEVGPEESGG ; EESGAEESGP ; EESDPEEPGA ; 100: AAEMEAGQPR ; PVLRSVNSCE ; PSQVIFCNRS ; PRVVLPVWLN ; FDGEPQPYPT ; 150: LPPGTGRRIH ; SYRGHLWLFR ; DAGTYDGLLV ; NQTELFVPSL ; NVDGQPIFAN ; 200: ITLPVYTLKE ; RCLQVVRSLV ; KPENYRRLDI ; VRSLYEDLED ; HPNVRKDLER ; 219: LAQEHIENQR ; MEGETEDFN
Sequence Length	219
String	Q5Q9Z2
Sub Unit	Part of a complex with Elongin BC complex and hydroxylated HIF1A. Interacts with CUL2. Part of multisubunit CBC(VHL) E3 ubiquitin ligase complexes with Elongin BC complex, CUL2 or CUL5 and RBX1. Interacts with HIF1AN. Part of a complex with HIF1A, HIF1AN and HDAC1 or HDAC2 or HDAC3. The C-terminus interacts with VBP1. Interacts with RNF139 and UBP33. Interacts with PHF17.

Reference	1. "cDNA sequence of canine von Hippel-Lindau disease tumor suppressor gene." Kobayashi N., Sato T., Shibuya H., Suzuki K. Submitted (2004-09) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]

Have you used this product?

SKU	Supplier No.	Size	Your price	Quantity
BHE13811921	E1894d	96T	$900		Add to Cart