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Home / Assay Kits / ELISA Kits

ELISA Kit for Dog Suppressor of cytokine signaling 3

SKU : BHE13809965

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1684d
Categories	Elisa
Function	SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin and leptin receptors. Inhibits JAK2 kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST.
Specificity	Natural and recombinant Dog Suppressor of cytokine signaling 3
Entryname	SOCS3_CANFA
Platform	PF00017
Protein Name	Suppressor of cytokine signaling 3
Sequence	50: MVTHSKFPAA ; GMSRPLDTSL ; RLKTFSSKSE ; YQLVVNAVCK ; LQESGFYWSA ; 100: VTGGEANLLL ; SAEPAGTFLI ; RDSSDQRHFF ; TLSVKTQSGT ; KNLRIQCEGG ; 150: SFSLQSDPRS ; TQPVPRFDCV ; LKLVHHYMPP ; PGAPSFPAPP ; TEPSSEVSEQ ; 200: PPSQPLPGNP ; PRRAYYIYSG ; GEKIPLVLSR ; PLSSNVATLQ ; HLCRKTVNGH ; 225: LDSYEKVTQL ; PGAIREFLDQ ; YDAPL
Sequence Length	225
String	Q68AM8
Sub Unit	Interacts with multiple activated proteins of the tyrosine kinase signaling pathway including IGF1 receptor, insulin receptor and JAK2. Binding to JAK2 is mediated through the KIR and SH2 domains to a phosphorylated tyrosine residue within the JAK2 JH1 domain. Binds specific activated tyrosine residues of the leptin, EPO, IL12, GSCF and gp130 receptors. Interaction with CSNK1E stabilizes SOCS3 protein. Component of the probable ECS(SOCS3) E3 ubiquitin-protein ligase complex which contains CUL5, RNF7/RBX2, Elongin BC complex and SOCS3. Interacts with CUL5, RNF7, TCEB1 and TCEB2. Interacts with FGFR3.

Uniprot	Q68AM8
Gene Name	SOCS3
Immunogen Species	Canis Lupus Familiaris (Dog)
Kegg	cfa:442949
Unigene	Cfa.3905

Reference	1. "Expression analysis of suppressor of cytokine signaling 3 (SOCS3) gene in canine atopic dermatitis." Tsukui T., Sakaguchi M., Maeda S., Koyanagi M., Masuda K., Ohno K., Tsujimoto H., Iwabuchi S. Submitted (2004-03) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]

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SKU	Supplier No.	Size	Your price	Quantity
BHE13809965	E1684d	96T	$900		Add to Cart

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