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Home / Assay Kits / ELISA Kits

ELISA Kit for Dog Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

SKU : BHE13809628

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E9568d
Categories	Elisa
Function	Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage.
Specificity	Natural and recombinant Dog Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
Subcellular Location	Cytoplasm Nucleus Nucleus nucleoplasm Nucleus nucleolus Primarily nuclear and largely excluded from the nucleolus. Highly mobile in cells and can be relocalized through interaction with targeting subunits. NOM1 plays a role in targeting this protein to the nucleolus. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles.
Entryname	PP1A_CANFA
Method Type	Sandwich
Platform	PF00149
Protein Name	Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
Sequence	50: MSDSEKLNLD ; SIIGRLLEVQ ; GSRPGKNVQL ; TENEIRGLCL ; KSREIFLSQP ; 100: ILLELEAPLK ; ICGDIHGQYY ; DLLRLFEYGG ; FPPESNYLFL ; GDYVDRGKQS ; 150: LETICLLLAY ; KIKYPENFFL ; LRGNHECASI ; NRIYGFYDEC ; KRRYNIKLWK ; 200: TFTDXFNXLP ; IAAIVDEKIF ; CCHGGLSPDL ; QSMEQIRRIM ; RPTDVPDQGL ; 250: LCDLLWSDPD ; KDVQGWGEND ; RGVSFTFGAE ; VVAKFLHKHD ; LDLICRAHQV ; 300: VEDGYEFFAK ; RQLVTLFSAP ; NYCGEFDNAG ; AMMSVDETLM ; CSFQILKPAD ; 330: KNKGKYGQFS ; GLNPGGRPIT ; PPRNSAKAKK ;
Sequence Length	330
String	Q8WMS6
Sub Unit	PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting or regulatory subunits. PPP1R12A, PPP1R12B and PPP1R12C mediate binding to myosin. PPP1R3A, PPP1R3B, PPP1R3C and PPP1R3D mediate binding to glycogen. Interacts with PPP1R15A and PPP1R15B; the interactions mediate binding to EIF2S1. Part of a complex containing PPP1R15B, PP1 and NCK1/2. Component of the MLL5-L complex, at least composed of MLL5, STK38, PPP1CA, PPP1CB, PPP1CC, HCFC1, ACTB and OGT. Interacts with PPP1R9A, PPP1R9B and PPP1R7. Interacts with YLPM1. Forms a complex with ILF2, ILF3, YLPM1, KHDRBS1, RBMX and NCOA5. Interacts with NOM1 and PPP1R8. Interacts with PPP1R16B. Interacts with RPSA only in the presence of PPP1R16B. Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1R10/PNUTS and PPP1R8. Interacts with WDR82 in the presence of PPP1R10/PNUTS. Interacts with SH3RF2. transition from mitosis into interphase. Interacts with TRIM28; the interaction dephosphorylates TRIM28 on 'Ser-824' and forms a complex at the p21 promoter site. Interacts with NEK2.

Uniprot	Q8WMS6
Gene Name	PPP1CA
Immunogen Species	Canis Lupus Familiaris (Dog)
Kegg	cfa:403609
Unigene	Cfa.3471

Reference	1. "Cloning of catalytic subunit of protein phosphatase type 1 alpha from dog heart." Mishra S., Sabbah H.N., Gupta R.C. Submitted (2001-11) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] tissue: Heart.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13809628	E9568d	96T	$900		Add to Cart

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