Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases.
Specificity
Natural and recombinant Dog Protein phosphatase 1 regulatory subunit 1A
"Cloning of inhibitor-1 of protein phosphatase type 1 from adult dog heart." Mishra S., Tiwari N., Sabbah H.N., Gupta R.C. Submitted (2001-11) to the EMBL/GenBank/DDBJ databases
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