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ELISA Kit for Dog Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

SKU : BHE13809386

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E14875d
Alternative Names	Mutated in multiple advanced cancers 1 ; Phosphatase and tensin homolog ; MMAC1
Categories	Elisa
Function	Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability.
Specificity	Natural and recombinant Dog Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Subcellular Location	Cytoplasm Nucleus Nucleus PML body Monoubiquitinated form is nuclear (By similarity). Nonubiquitinated form is cytoplasmic. Colocalized with PML and USP7 in PML nuclear bodies.
Entryname	PTEN_CANFA
Method Type	Sandwich
Platform	PF00782
Protein Name	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Sequence	50: MTAIIKEIVS ; RNKRRYQEDG ; FDLDLTYIYP ; NIIAMGFPAE ; RLEGVYRNNI ; 100: DDVVRFLDSK ; HKNHYKIYNL ; CAERHYDTAK ; FNCRVAQYPF ; EDHNPPQLEL ; 150: IKPFCEDLDQ ; WLSEDDNHVA ; AIHCKAGKGR ; TGVMICAYLL ; HRGKFLKAQE ; 200: ALDFYGEVRT ; RDKKGVTIPS ; QRRYVYYYSY ; LLKNHLDYRP ; VALLFHKMMF ; 250: ETIPMFSGGT ; CNPQFVVCQL ; KVKIYSSNSG ; PTRREDKFMY ; FEFPQPLPVC ; 300: GDIKVEFFHK ; QNKMLKKDKM ; FHFWVNTFFI ; PGPEETSEKV ; ENGSLCDQEI ; 350: DSICSIERAD ; NDKEYLVLTL ; TKNDLDKANK ; DKANRYFSPN ; FKVKLYFTKT ; 400: VEEPSNPEAS ; SSTSVTPDVS ; DNEPDHYRYS ; DTTDSDPENE ; PFDEDQHTQI ; 403: TKV
Sequence Length	403
String	P60483
Sub Unit	Monomer. The unphosphorylated form interacts with the second PDZ domain of AIP1. Interacts with MAGI2, MAGI3, MAST1 and MAST3, but neither with MAST4 nor with DLG5; interaction with MAGI2 increases protein stability (By similarity). Interacts with NEDD4. Interacts with NDFIP1 and NDFIP2; in the presence of NEDD4 or ITCH, this interaction promotes PTEN ubiquitination (By similarity). Interacts (via C2 domain) with FRK (By similarity). Interacts with USP7; the interaction is direct (By similarity). Interacts with ROCK1.

Uniprot	P60483
Gene Name	PTEN
Immunogen Species	Canis Lupus Familiaris (Dog)
Kegg	cfa:403832
Unigene	Cfa.3695

Reference	1. "Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers." Steck P.A., Pershouse M.A., Jasser S.A., Lin H., Yung W.K.A., Ligon A.H., Langford L.A., Baumgard M.L., Hattier T., Davis T., Frye C., Hu R., Swedlund B., Teng D.H.-F., Tavtigian S.V. Nat. Genet.15:356-363(1997) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]

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SKU	Supplier No.	Size	Your price	Quantity
BHE13809386	E14875d	96T	$900		Add to Cart

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