Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.
Specificity
Natural and recombinant Dog Lymphotoxin-alpha
Subcellular Location
Secreted Membrane The homotrimer is secreted (By similarity). The heterotrimer is membrane-associated.
"Gemomic map of a portion of the canine MHC class I histocompatibility complex." Wagner J.L., Palti Y., DiDario D.D. Submitted (2003-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]