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Home / Assay Kits / ELISA Kits

ELISA Kit for Dog GTP-binding nuclear protein Ran

SKU : BHE13809045

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E15339d
Alternative Names	GTPase Ran ; Ras-like protein TC4 ; Ras-related nuclear protein
Categories	Elisa
Function	GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2.
Specificity	Natural and recombinant Dog GTP-binding nuclear protein Ran
Subcellular Location	Nucleus Cytoplasm Melanosome Predominantly nuclear during interphase (By similarity). Becomes dispersed throughout the cytoplasm during mitosis.
Entryname	RAN_CANFA
Platform	PF00071
Protein Name	GTP-binding nuclear protein Ran
Sequence	50: MAAQGEPQVQ ; FKLVLVGDGG ; TGKTTFVKRH ; LTGEFEKKYV ; ATLGVEVHPL ; 100: VFHTNRGPIK ; FNVWDTAGQE ; KFGGLRDGYY ; IQAQCAIIMF ; DVTSRVTYKN ; 150: VPNWHRDLVR ; VCENIPIVLC ; GNKVDIKDRK ; VKAKSIVFHR ; KKNLQYYDIS ; 200: AKSNYNFEKP ; FLWLARKLIG ; DPNLEFVAMP ; ALAPPEVVMD ; PALAAQYEHD ; 216: LEVAQTTALP ; DEDDDL
Sequence Length	216
String	P62825
Sub Unit	Monomer (By similarity). Also forms a complex with CHC1. Found in a complex with nuclear export signal-cargo peptides, RANBP3 and XPO1. Component of a nuclear export receptor complex composed of KPNB1, Ran, SNUPN and XPO1. Found in a trimeric export complex with SNUPN, Ran and XPO1. Interacts with RANBP10. Interacts in its GTP-bound form with BIRC5/survivin at S and M phases of the cell cycle. Interacts with TERT; the interaction requires hydrogen peroxide-mediated phosphorylation of TERT and transports TERT to the nucleus. Interacts with MAD2L2 (By similarity). Interacts with RANBP10 (By similarity). Interacts with VRK1, VRK2 and VRK3.

Uniprot	P62825
Gene Name	RAN
Immunogen Species	Canis Lupus Familiaris (Dog)
Kegg	cfa:100499482
Unigene	Cfa.50

Reference	1. "Sequence of a canine cDNA clone encoding a Ran/TC4 GTP-binding protein." Dupree P., Olkkonen V.M., Chavrier P. Gene120:325-326(1992) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: Cocker spaniel. tissue: Kidney. 2. "Structural basis for molecular recognition between nuclear transport factor 2 (NTF2) and the GDP-bound form of the Ras-family GTPase Ran." Stewart M., Kent H.M., McCoy A.J. J. Mol. Biol.277:635-646(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF COMPLEX WITH NTF2 3. "The structure of the Q69L mutant of GDP-Ran shows a major conformational change in the switch II loop that accounts for its failure to bind nuclear transport factor 2 (NTF2)." Stewart M., Kent H.M., McCoy A.J. J. Mol. Biol.284:1517-1527(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) OF MUTANT LEU-69

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SKU	Supplier No.	Size	Your price	Quantity
BHE13809045	E15339d	96T	$900		Add to Cart

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