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Home / Assay Kits / ELISA Kits

ELISA Kit for Dog G1/S-specific cyclin-D1

SKU : BHE13801998

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0585d
Categories	Elisa
Function	Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
Specificity	Natural and recombinant Dog G1/S-specific cyclin-D1
Subcellular Location	Nucleus Cytoplasm Membrane Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members.
Entryname	CCND1_CANFA
Platform	PF02984
Protein Name	G1/S-specific cyclin-D1
Sequence	50: MAHQLLCCEV ; ETIRRAYPDA ; NLLNDRVLRA ; MLKAEETCAP ; SVSYFKCVQK ; 100: EILPSMRKIV ; ATWMLEVCEE ; QKCEEEVFPL ; AMNYLNRFLS ; LEPVKKSRLQ ; 150: LLGATCMFVA ; SKMKETIPLT ; AEKLCIYTDN ; SIRPDELLQM ; ELLLVNKLKW ; 200: NLAAMTPHDF ; IEHFLSKMPV ; AEENKQIIRK ; HAQTFVALCA ; TDVKFISNPP ; 250: SMVAAGSVVA ; AVQGLHLGSS ; NSFLSYHRLT ; RFLSKVIKCD ; ADCLRACQEQ ; 295: IEALLESSLR ; QAQQQSLDPK ; AAEEEEEEEE ; ADLACTPTDV ; RDVNI
Sequence Length	295
String	Q64HP0
Sub Unit	Interacts with either CDK4 or CDK6 protein kinase to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Component of the ternary complex cyclin D/CDK4/CDKN1B required for nuclear translocation and modulation of CDK4-mediated kinase activity. Interacts directly with CDKN1B. Can form similar complexes with either CDKN1A or CDKN2A. Interacts with USP2 and FBXO4.

Uniprot	Q64HP0
Gene Name	CCND1
Immunogen Species	Canis Lupus Familiaris (Dog)
Kegg	cfa:449028
Unigene	Cfa.16248

Reference	1. "Molecular characterization and mapping of the canine cyclin D1 (CCND1) gene." Meyer B., Murua Escobar H., Winkler S., Dolf G., Schelling C., Bullerdiek J., Nolte I. Anim. Genet.35:413-413(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] tissue: Osteosarcoma.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13801998	E0585d	96T	$900		Add to Cart

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