Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission.
Specificity
Natural and recombinant Dog Dystrophin
Subcellular Location
Cell membrane sarcolemma Peripheral membrane protein Cytoplasmic side Cytoplasm cytoskeleton
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