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Home / Assay Kits / ELISA Kits

ELISA Kit for Dog Cellular tumor antigen p53

SKU : BHE13808501

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0928d
Alternative Names	Tumor suppressor p53 ; P53
Categories	Elisa
Function	Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression.
Specificity	Natural and recombinant Dog Cellular tumor antigen p53
Subcellular Location	Cytoplasm Nucleus Endoplasmic reticulum Interaction with BANP promotes nuclear localization.
Entryname	P53_CANFA
Platform	PF00870
Protein Name	Cellular tumor antigen p53
Sequence	50: MEESQSELNI ; DPPLSQETFS ; ELWNLLPENN ; VLSSELCPAV ; DELLLPESVV ; 100: NWLDEDSDDA ; PRMPATSAPT ; APGPAPSWPL ; SSSVPSPKTY ; PGTYGFRLGF ; 150: LHSGTAKSVT ; WTYSPLLNKL ; FCQLAKTCPV ; QLWVSSPPPP ; NTCVRAMAIY ; 200: KKSEFVTEVV ; RRCPHHERCS ; DSSDGLAPPQ ; HLIRVEGNLR ; AKYLDDRNTF ; 250: RHSVVVPYEP ; PEVGSDYTTI ; HYNYMCNSSC ; MGGMNRRPIL ; TIITLEDSSG ; 300: NVLGRNSFEV ; RVCACPGRDR ; RTEEENFHKK ; GEPCPEPPPG ; STKRALPPST ; 350: SSSPPQKKKP ; LDGEYFTLQI ; RGRERYEMFR ; NLNEALELKD ; AQSGKEPGGS ; 381: RAHSSHLKAK ; KGQSTSRHKK ; LMFKREGLDS ; D
Sequence Length	381
String	Q29537
Sub Unit	Binds DNA as a homotetramer. Found in a complex with CABLES1 and TP73. Interacts with histone acetyltransferases EP300 and methyltransferases HRMT1L2 and CARM1, and recruits them to promoters. The C-terminus interacts with TAF1, when TAF1 is part of the TFIID complex. Interacts with HIPK1, HIPK2, AXIN1, and P53DINP1. Part of a complex consisting of TP53, HIPK2 and AXIN1. Interacts with WWOX. Interacts with USP7 and SYVN1. Interacts with HSP90AB1. Interacts with ARMD10, BANP, CDKN2AIP, NUAK1, STK11/LKB1 and E4F1. Interacts with CHD8, leading to recruit histone H1 and prevent transactivation activity. Interacts with YWHAZ; the interaction enhances TP53 transcriptional activity. Phosphorylation of YWHAZ on 'Ser-58' inhibits this interaction. Directly interacts with FBXO42; leading to ubiquination and degradation of TP53. Interacts with AURKA, DAXX, BRD7 and TRIM24. Interacts (when monomethylated at Lys-370) with L3MBTL1 (By similarity). Interacts with GRK5. Binds to the CAK complex (CDK7, cyclin H and MAT1) in response to DNA damage. Interacts with CDK5 in neurons.

Uniprot	Q29537
Gene Name	TP53
Immunogen Species	Canis Lupus Familiaris (Dog)
Kegg	cfa:403869
Unigene	Cfa.3658

Reference	1. "Isolation of canine p53 cDNA and detailed characterization of the full length canine p53 protein." Veldhoen N., Milner J. Oncogene16:1077-1084(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] tissue: Leukocyte. 2. "Aberrations of p53 tumor suppressor gene in various spontaneous tumors in the dog." Setoguchi A., Sakai T., Okuda M., Minehata K., Yazawa M., Ishizaka T., Watari T., Hasagawa A., Tsujimoto H. Submitted (1998-12) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] tissue: Spleen. 3. "Sequence analysis of canine p53 in the region of exons 3-8." Kraegel S.A., Pazzi K.A., Madewell B.R. Cancer Lett.92:181-186(1995) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 25-300 strain: Beagle.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13808501	E0928d	96T	$900		Add to Cart

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