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Home / Assay Kits / ELISA Kits

ELISA Kit for Dog C-X-C chemokine receptor type 4

SKU : BHE13803174

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2170d
Alternative Names	CD184
Categories	Elisa
Function	Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival.
Specificity	Natural and recombinant Dog C-X-C chemokine receptor type 4
Subcellular Location	Cell membrane Multi-pass membrane protein In unstimulated cells, diffuse pattern on plasma membrane. On agonist stimulation, colocalizes with ITCH at the plasma membrane where it becomes ubiquitinated.
Detection Range	0.156-10ng/mL
Entryname	CXCR4_CANFA
Method Type	Sandwich
Platform	PF00001
Protein Name	C-X-C chemokine receptor type 4
Sensitivity	0.083ng/mL
Sequence	50: MEELHIYPSD ; NYTEEDLGSG ; DYDSMKEPCF ; REENAHFNRI ; FLPTVYSIIF ; 100: LTGIVGNGLV ; ILVMGYQKKL ; RSMTDKYRLH ; LSVADLLFVL ; TLPFWAVEAV ; 150: ANWYFGNFLC ; KAVHVIYTVN ; LYSSVLILAF ; ISLDRYLAIV ; HATNSQRPRK ; 200: LLAEKVVYVG ; VWIPALLLTI ; PDFIFANVRE ; ADDRYICDRF ; YPNDSWLVVF ; 250: QFQHIMVGLI ; LPGIVILSCY ; CIIISKLSHS ; KGYQKRKALK ; TTVILILAFF ; 300: ACWLPYYIGI ; SIDSFILLEI ; IKQGCEFEKT ; VHKWISITEA ; LAFFHCCLNP ; 350: ILYAFLGAKF ; KTSAQHALTS ; VSRGSSLKIL ; SKGKRGGHSS ; VSTESESSSF ; 353: HSS
Sequence Length	353
String	Q3LSL6
Sub Unit	Monomer (By similarity). Can form dimers (By similarity). Interacts with CD164. Interacts with ARRB2; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and allows activation of MAPK1 and MAPK3. Interacts with ARRC; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and modulates calcium mobilization. Interacts (via the cytoplasmic C-terminal) with ITCH (via the WW domains I and II); the interaction, enhanced by CXCL12, ubiquitinates CXCR4 and leads to its degradation. Interacts with extracellular ubiquitin; the interaction enhances intracellular calcium ions and reduces cellular cAMP levels.

Uniprot	Q3LSL6
Gene Name	CXCR4
Immunogen Species	Canis Lupus Familiaris (Dog)
Kegg	cfa:483900
Unigene	Cfa.16645

Reference	1. "Evaluation of the canine CXCR4 and CXCL12 genes as a candidate for chronic neutropenia with myelokathexis in a border collie dog." Tsuchida S., Kagi A., Takahashi T. Submitted (2005-08) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]

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SKU	Supplier No.	Size	Your price	Quantity
BHE13803174	E2170d	96T	$900		Add to Cart

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